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Wnt1在胃癌中的表达及与临床病理特征的关系 被引量:2

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摘要 目的观察Wnt1在胃癌组织中的表达,探讨其与临床病理特征的关系。方法对45例人胃癌组织标本及肿瘤边缘5 cm以外的正常组织进行LSAB免疫组化检测和平均光密度(AOD)测定。结果 45例胃癌组织中,Wnt1阳性表达率为57.78%,与正常组织相比,差异有统计学意义(P<0.01)。高分化、中分化、低分化的阳性率分别为36.84%、62.50%、90%,分化程度之间差异有统计学意义(P<0.05)。平均AOD测定结果示淋巴结有转移组明显高于无转移组(P<0.01),并且与肿瘤分期和浸润深度相关(均P<0.01)。结论 Wnt1在胃癌中高表达,与其发生、发展关系密切。
出处 《广东医学》 CAS CSCD 北大核心 2010年第15期1982-1984,共3页 Guangdong Medical Journal
基金 河北省张家口市科技攻关计划项目(编号:091111D)
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