摘要
目的:研究汕头地区鼻腔、鼻窦内翻性乳头状瘤中人乳头状瘤病毒(HPV)蛋白的表达,并探讨HPV在内翻性乳头状瘤发生、发展过程中的意义。方法:用免疫组化EnVision两步法对49例鼻腔、鼻窦内翻性乳头状瘤和11例鼻慢性炎症及鼻炎性息肉石蜡标本进行HPV(广谱型)蛋白表达的检测。结果:①HPV蛋白在鼻腔、鼻窦单纯内翻性乳头状瘤和内翻性乳头状瘤癌变/乳头状癌两组中均有表达,总HPV阳性感染率为34.7%(17/49),而11例鼻慢性炎症及鼻炎性息肉组织中均无表达。②HPV阳性感染率在34例单纯内翻性乳头状瘤组织中为38.2%(13/34),在15例内翻性乳头状瘤癌变/乳头状癌中为26.7%(4/15),其组间的HPV阳性率无统计学意义。③鼻慢性炎症及鼻炎性息肉组与鼻腔、鼻窦单纯内翻性乳头状瘤和内翻性乳头状瘤癌变/乳头状癌组组间的HPV阳性率均有统计学意义(P<0.05)。结论:HPV感染可能与鼻腔、鼻窦内翻性乳头状瘤和内翻性乳头状瘤癌变/乳头状癌的发生密切相关,但与鼻腔、鼻窦内翻性乳头状瘤的癌变过程的关系有待进一步研究。
Objective： To investigate the expression of human papilloma vires in the sinonasal inverted papilloma and papillous squamous cell carcinoma, and to study the correlation of the expression of HPV with development and progression of the sinonasal inverted papilloma. Methods： HPV（wide-spectrum model）protein expression in 49 paraffin tissue specimen of sinonasal, including inverted papilloma, papillous squamous cell carcinoma and 11 paraffin tissue specimen of chronic inflammations（nasal polypus）were detected using immunohistochemieal EnVision two step method. Results： HPV in the inverted papilloma and papillous squamous cell carcinoma was observed, the overall positive rate of HPV was 34.7%（17/49）. Expression of HPV was not found in 11 chronic inflammations（nasal polypus）. The positive rate of HPV was 38.2% （13/34）in the s inonasal inverted papilloma, 26.7 % （4/15）in the papillous squamous cell carcinoma. The correlation of the sinonasal inverted papilloma and the papillous squamous cell carcinoma was not statistically significant in the positive rate of HPV. The correlation of chronic inflammation（nasal polypus）and inverted papilloma, papillous squamous ceil carcinoma was statistically significant in the positive rate of HPV（P 〈 0.05）. Conclusion： HPV infection is likely to have close correlation with the development of sinonasal inverted papilloma and papillous squamous cell carcinoma. Nevertheless, the correlation needs further research between HPV infection and carcinogenesis of sinonasal inverted papilloma.
出处
《汕头大学医学院学报》
2010年第3期152-154,F0002,共4页
Journal of Shantou University Medical College
