摘要
目的探讨糖皮质激素（ＧＣ）对毛细血管内增生性肾炎（ＥＰＧＮ）致肾病综合征（ＮＳ）的治疗作用。方法采取开放对照研究，对９例ＥＰＧＮ性ＮＳ，病程４周无好转的患者，给予大剂量标准疗程的强的松治疗，治疗结果与常规治疗组进行对比。结果强的松组９例中，治疗２个月后７例获得完全缓解（７７．８％），１２个月后９例全部达到完全缓解（１００％）。常规治疗组１０例中，在相应时间观察到的完全缓解人数分别为２例（２０．０％）和５例（５０．０％），两组间两个时期完全缓解率均有显著性差异（Ｐ＜０．０５）。结论对ＥＰＧＮ性ＮＳ，使用强的松治疗可以有效地减少蛋白尿，使患者早日达到完全缓解。
bjective To identify the effect of glucocorticoid(GC) on the nephrotic syndrome(NS) from endocapillary proliferative glomerulonephritis(EPGN). Methods An open, contrasted study was conducted. Cases with NS from EPGN were divided into two groups, one of them was treated with conventional therapy and another one with a large dose of prednisone based on conventional way. The result was compared and analysed. Results The total number of entirely remission was 7 cases(77.8%) within two months and 9 cases(100%) within 12 months after treatment in prednisone group. Compared with 2 cases(20%) and 5 cases(50%) in control group, the difference of entirely remissiom rate was statistically significant. Conclusion Prednisone is effective on the NS from EPGN to reduce proteinuria and make entirely remission earlier.
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
1999年第3期155-157,共3页
Chinese Journal of Nephrology
