摘要
目的：探讨血清总唾液酸对食管癌早诊的作用。方法：采用化学比色法对我国食管癌高发区之一—磁县１５１０例普查人群的血清总唾液酸（ＴＳＡ）分析研究。结果：高发人群血清ＴＳＡ含量随食管上皮细胞增生加重逐渐增加。方差分析显示食管癌、近癌、重增Ⅱ与重增Ⅰ、轻增、正常人群血清ＴＳＡ含量具有显著性差异（Ｐ＜００１），食管各级病变血清ＴＳＡ含量两两比较的ｑ检验结果表明：在食管上皮细胞重增Ⅱ时ＴＳＡ含量与正常人群就有显著性差异（Ｐ＜００１），而重增Ⅰ、轻增和正常人群ＴＳＡ无显著性差异（Ｐ＞００５）。
Levels of serum total sialic acid (TAS) among 1510 subjects from cixian,one of the place highest incidence of esophageal cancer were detected by technique of chemical colorimetric method.The results show that TSA levels increase with extent of hyperplasia in esophageal epithelial cell.Analysis of variance show the difference of serum TSA levels were significant among esophageal cancer,near cancer,dysplasia Ⅱ and dysplasia I,hyperplasia,normal ( P <0 01).q test between all grading lesion show TSA levels were significant in dysplasia Ⅱ with normal ( P <0 01).While TSA levels were not in dysplasia Ⅰ with normal ( P >0 05).The assay indicate that levels of serum TSA may be helpful as a norm of early diagnosis of esophageal cancer among subjects.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1999年第3期171-173,共3页
Cancer Research on Prevention and Treatment
基金
国家"八五"公关课题
关键词
食管癌
化学比色法
血清
总唾液酸
诊断
esophageal cancer
chemical colorimetic method
Serum total sialic acid
