摘要
目的：研究绿茶素对肿瘤的预防和辅助治疗作用。方法：采用我院从湖北绿茶提取的绿茶素（ＴＰ９１）进行了多项指标综合观察的抗肿瘤实验。瘤株为小鼠Ｓ１８０，Ｈｅｌａ细胞和ＥＡＣ。结果：（１）ＴＰ９１具明显抗癌作用，对Ｓ１８０的抑瘤率达４３６％，体外试验对Ｈｅｌａ细胞和ＥＡＣ细胞均有抑制作用，药物作用２小时后癌细胞死亡率分别为９３％和４５％；（２）给药后血液高凝状态缓解、ｃＡＭＰ升高、ＳＯＤ活性增强，外周血Ｔ淋巴细胞百分率上升、以及肿瘤间质肥大细胞数增多；（３）检出ＴＰ９１含有硒、锗等２０种元素。
This paper presents
our recent results from a multiparameter observation of the anticancer activity of Luchasu
(TP91) against mice tumor systems.TP91 was isolated from Chinese green tea.NIH mice were
transplanted with S180 subcutaneously,and randomly divided into two groups,viz.,Luchasu
(TP91) group and control group.Dosage of TP91 was 150 mg/kg/day,oral administration for
seven days.control group received N.S. only.The results showed that Luchasu (TP91)
possessed tumor suppressive effect.The inhibition rate for mice S180 was 436%.Luchasu
(TP91) also inhibited growth of cultured Hela cells as well as EAC cells,as in vitro studies
showed.Laboratory tests demonstrated that Luchasu (TP91) reduced blood
coagulability,increased cAMP and SOD levels,and increased numbers of peripheral
Tlymphocytes and stromal mast cells.Chemically,Luchasu (TP91) is a compound mainly
contains EGCG and trace elements such as selenium and germinium.In the paper,mechanisms
of action were discussed.It is of the authors opinion that Luchasu (TP91) is promising in
chemoprevention and adjuvant therapy for human cancer.Further study is worth continuing.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1999年第3期161-163,共3页
Cancer Research on Prevention and Treatment
基金
武汉市科委资助
关键词
绿茶素
肿瘤
预防
治疗
实验研究
Luchasu (TP91)green tea extract
tumor
S180
experimental therapy
