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生存质量作为时变协变量的Cox回归分析及应用 被引量:8

Quality of Life as A Time dependent Covariable in Cox Regression Analysis and Its Application
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摘要 目的提出一种综合分析生存质量与生存时间的统计方法,并探讨有关的应用问题。方法基于Cox回归模型,提出将生存质量作为时变协变量的Cox回归分析法,并用于212例吸毒者戒毒效果的影响因素分析。结果进入回归方程的因素及风险比分别为:戒毒方式(0.673)、婚姻状况(1.315)、吸毒方式(1.319)、戒毒次数(0.867)、母亲文化程度(1.120)、母亲职业(1.318)、家庭环境气氛(0.724)、能否得到亲朋帮助(1.150)。结论综合分析生存质量与生存时间的统计方法是一种较好的分析方法。对戒毒效果的影响因素分析表明,主要取决于母亲素质、家庭好坏和吸毒方式、吸毒时间长短等。 Objective To present a statistical method for combined evaluation of the quality of life and survival time and to study some issues in its application. Methods Based on Cox regression model, quality of life was used as a time dependent covariable in analysis of the influence factors for the effectiveness of detoxification in 212 drug addicts. Results The influence factors entered the regression equation were ways of detoxification for drug abusers, marital status, mode of drug abuse, frequency of detoxification, maternal educational level, maternal occupation, family atmosphere and help and encourage from their relatives and friends, with their hazard ratios of 0.673, 1.315, 1.319, 0.867, 1.120, 1.318, 0.724 and 1.150, respectively. Conclusion Combined statistical analysis of quality of life and survival time was a better method for the evaluation of the effectiveness of detoxification and its influence factors, which depended mainly on their mother's qualification, family atmosphere, mode and length of drug abuse, etc.
出处 《中华预防医学杂志》 CAS CSCD 北大核心 1999年第3期143-145,共3页 Chinese Journal of Preventive Medicine
基金 高等学校博士点学科专项科研基金
关键词 生活质量 回归分析 吸毒 卫生统计 统计方法 Quality of life Regression analysis Substance related disorders
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参考文献4

  • 1万崇华 方积乾.海洛因成瘾者生存质量测定量表的制定及其考评[J].中国行为医学科学杂志,1997,6:169-172.
  • 2万崇华 方积乾.质量-数量生存分析[J].中国社会医学,1995,(4):5-8.
  • 3万崇华,中国行为医学科学,1997年,6卷,169页
  • 4万崇华,中国社会医学,1995年,4期,5页

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