摘要
目的比较β－七叶皂甙钠和甘露醇及地塞米松治疗放射性脑水肿的疗效。方法４９例经头颅ＣＴ或（和）ＭＲＩ证实的放射性脑水肿随机分为甘露醇对照组［１１例，１ｇ／（ｋｇ·ｄ）］、地塞米松对照组（１１例，２０ｍｇ／ｄ）、单纯β－七叶皂甙钠治疗组（１４例）和β－七叶皂甙钠并用甘露醇组（１３例）。后２组均采用β－七叶皂甙钠２０ｍｇ溶于２５０ｍＬ生理盐水中静滴。结果单纯β－七叶皂甙钠治疗组有效比例为１３／１４，２个β－七叶皂甙钠治疗组总有效比例为２６／２７，明显高于甘露醇组（７／１１）和单纯地塞米松（８／１）组。结论β－七叶皂甙钠治疗放射性脑水肿有效，且优于甘露醇和地塞米松。
Objective To study the efficacy of β aescine sodium, mannitol, dexamethasone on treatment of radiative brain edema.Methods Forty nine patients with radiative brain edema were randomly divided into four groups: fourteen patients were treated with β aescine sodium 20 mg in 250 mL of 0.9% sodium chloride injection, iv drip, every day. Thirteen patients were treated with β aescine 20 mg plus mannitol [1 g/(kg·d)]. Eleven patients were treated with mannitol [1 g/(kg·d)], and 11 patients with dexamethasone (20 mg/d).Results The total efficacy rates(26/27) in β aescine sodium groups was higher than that of groups of mannitol (7/11) and dexamethasone (8/11).Conclusions β aescine sodium has a good effect on radiative brain edema and more advantages than mannitol and dexamethasone. There is a better effect on radiative brain edema when it is used with mannitol.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
1999年第3期150-152,共3页
Chinese Journal of Nervous and Mental Diseases
