摘要
目的 探索卡贝缩宫素预防剖宫产术后出血的治疗效果.方法 选择具有剖宫产指征且有宫缩乏力高危因素的孕妇150例,排除使用卡贝缩宫素及米索前列醇的禁忌症,随机分为研究组（卡贝缩宫素组）和对照1组（缩宫素组）、对照2组（米索前列醇组）,各50例;准确收集术中及产后24小时出血量,比较各组手术前后血红蛋白浓度（Hb）的变化、术中及术后24小时出血量,产后出血的发生率、不良事件的发生等,综合评价卡贝缩宫素预防剖宫产术后出血的治疗效果及安全性.结果 研究组产后24小时出血量及出血发生率分别：（226.1±54.29）ml、2%;对照1、2组产后24小时出血量及产后出血发生率分别为：（386.1±111.89）ml、（336.4±102.83）ml、12%、8%;研究组与对照1,2组比较,差异具有极显著性（P＜0.001）.研究组产后24小时血红蛋白下降（1.18±0.3）g,对照1、2组产后24小时血红蛋白分别下降（1.95±0.54）g、（1.52±0.54）g;研究组与对照1,2组比较,差异具有极显著性（P＜0.001）.50例应用卡贝缩宫素的产妇中,只有3例出现轻度面部潮红和轻度发热,无出现其他不适症状和血液学检查异常,它的安全性与催产素相当.结论 卡贝缩宫素有预防剖宫产术中产后出血的作用,其效果优于其他宫缩剂,且具有安全、高效、迅速、给药方便等优点.
Objective To observe the effects of Duratocin on reduction of postpartum bleading in Cesareansection.Method Select a cesarean and hypodynamic risk factots of 150cases of pregnant women, preclude the use of Duratocin and misoprostol contraindications, divided into research group （Duratocin group） and control 1 Group （oxytocin group）, controlled 2 Group （misoprostol group）,accutate collection of postpartum hemorrhage,24-hour comparison group for hemoglobin concentration （Hb） changes, and 24-hour blood loss, the incidence of postpartum hemorrhage, adverse events occurred, comprehensive evaluation Duratocin Cesarean treatment efficacy and safety.Results Duratocin group Hb concentration of before and after surgery and post-operative blood loss 24 hours,the incidence of postpartum hemorrhage, adverse events occur, and so on, are significantly lower than reference 1,2,P〈0.001, significant difference, statistically significance,Conchusion Duratocin, known as the Caesarian role in postpamm hemorrhage, the effect is better than other Palace admixture, and have a safe, efficient, fast, easy delivery.Just one intravenously to achieve continuous infusion oxytocin 16 hours to the same effect.
出处
《国际医药卫生导报》
2010年第22期2754-2756,共3页
International Medicine and Health Guidance News
关键词
产后出血
剖宫产
卡贝缩宫素
Postpartum hemorrhage
Cesatean section
Duratocin
