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胰腺癌早期诊断研究现状及展望 被引量:18

Status and prospects of early diagnosis of pancreatic cancer
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摘要 近年来胰腺癌的发病率和病死率呈逐年上升趋势。胰腺癌早期诊断困难、预后极差,大多数胰腺癌诊断明确时已属中晚期。手术切除目前仍被认为是唯一可能根治胰腺癌的治疗方法。据美国SEER统计,2001年胰腺癌的总体5年生存率是5.2%,经根治性手术切除患者的5年生存率为18%,淋巴结阴性者为32%,切缘与淋巴结均为阴性者则是41%。因此,寻求胰腺癌早期诊断方法可能是目前改善预后的关键。然而,目前尚无单一特异的早期诊断胰腺癌的方法。
作者 李兆申
出处 《临床肝胆病杂志》 CAS 2010年第5期451-453,458,共4页 Journal of Clinical Hepatology
关键词 胰腺肿瘤 早期诊断 pancreatic neoplasms early diagnosis
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参考文献23

  • 1Cameron JL, Riall TS, Coleman J, et al. One thousand consecutive pancreaticoduodenectomies[ J]. Ann Surg,2006,244( 1 ) : 10 - 15.
  • 2Brat D J, Lillemoe KD, Yeo C J, et al. Progression of pancreatic intraductal neoplasias to infiltrating adenocarcinoma of the pancreas[ J]. Am J Surg Pathol, 1998,22(2 ) : 163 - 169.
  • 3Pelaez - Luna M, Takahashi N, Fletcher JG, et al. Resectability of presymptomatic pancreatic cancer and its relationship to onset of diabetes : a retrospective review of CT scans and fasting glucose values prior to diagnosis[ J]. Am J Gastroenterol,2007,102(10) : 2157 2163.
  • 4Lynch SM, Vrieling A, Lubin JH, et al. Cigarette smoking and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium [J]. Am J Epidemiol, 2009,170 (4) : 403 - 413.
  • 5Lowenlels AB, Maisonneuve P, Cavallini G, et al. Pancreatitis and the risk of pancreatic cancer[J]. N Engl J Med, 1993,328(20) : 1433 - 1437.
  • 6Bracci PM, Wang F, Hassan MM, et al. Panereatitis and pancreatic cancer in two large pooled case - control studies[ J]. Cancer Causes Control,2009,20(9) : 1723 - 1731.
  • 7Chari ST, Leibson CL, Rabe KG, et al. Probability of pancreatic cancer following diabetes : a population - based study [ J ]. Gastroenterology,2005,129 ( 2 ) : 504 - 511.
  • 8Teich N. Pancreatic cancer: cause and result of diabetes mellitus[ J]. Gastroenterology ,2008,134 ( 1 ) : 344 - 345.
  • 9Pannala R, Leibson CL, Rabe KG, et al. Temporal association of changes in fasting blood glucose and body mass index with diagnosis of pancreatic cancer[ J ]. Am J Gastroenterol,2009,104 ( 9 ) : 2318 - 2325.
  • 10Senior K. Late - onset diabetes and the link with pancreatic cancer[ J]. Lancet Oncol,2005,6(9):641.

二级参考文献12

  • 1Bos J L.Ras oncogenes in human cancer:a review,1989.
  • 2Ochi K;Hasuoka H;Mizushima Y.A case of small pancreatic cancer diagnosed by serial follow-up studies promptly by a positive K-ras point mutation in pure pancreatic juice,1998.
  • 3Mulcahy H;Farthing MJ.Diagnosis of pancreatico-biliary malignancy:detection of gene mutations in plasma and stool[J],1999(Suppl 4).
  • 4Mulcaty HE;Lyautey J;Lederrey C.A prospective study of K-ras mutations in the plasma of pancreatic cancer patients[J],1998(02).
  • 5Theodor L;Melzer E;Sologov M.Detection of pancreatic carcinoma:diagnostic value of K-ras mutations in circulating DNA from serum[J],1999(10).
  • 6Tada M;Omata M;Kawai S.Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma,1993(11).
  • 7Kimura W;Zhao B;Futakawa N.Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas,1999(46).
  • 8Myung SJ;Kim MH;Kim YS.Telomerase activity in purepancreatic juice for the diagnosis of pancreatic cancer may be complementary to K ras mutation[J],2000(06).
  • 9Van Laethem JL;Vertongen P;Deviere J.Detection of c-Ki-ras gene codon 12 mutations from pancreatic duct brushings in the diagnosis of pancreatic tumours[J],1995(05).
  • 10Luttges J;Schlehe B;Menke MA.The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal,hyperplastic,and metaplastic ductal epithelium,1999(08).

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