摘要
目的探讨急性脑卒中患者血浆内皮源性血管活性物质内皮素（ＥＴ）、血栓素Ｂ２（ＴＸＢ２）、６酮前列腺素Ｆ１α（６ＫＰＧＦ１α）浓度变化及其与局部脑血流量（ｒＣＢＦ）的关系。方法应用放射免疫分析法测定６４例脑卒中患者和３０例正常对照者的血浆ＥＴ、ＴＸＢ２、６ＫＰＧＦ１α浓度，并同步应用１３３Ｘｅ吸入法测定ｒＣＢＦ。结果脑卒中患者血浆ＥＴ含量为（１０３８±４２６）ｎｇ／Ｌ、ＴＸＢ２为（１５２２±５９１）ｎｇ／Ｌ，正常对照组分别为（４７８±７８）ｎｇ／Ｌ和（８４８±１１５）ｎｇ／Ｌ，两者相比，差异均有显著性（Ｐ均＜００１）；而６ＫＰＧＦ１α含量为（９３７±２８８）ｎｇ／Ｌ，较正常对照组的（１０４７±１７４）ｎｇ／Ｌ显著下降（Ｐ＜００５）。脑卒中患者左、右半球和平均ｒＣＢＦ分别为（４６６±８８）、（４７２±８２）和（４６９±７９）ｍＬ·１００ｇ－１·ｍｉｎ－１，明显低于正常对照组的（６２２±７１）、（６４５±７１）和（６３３±６５）ｍＬ·１００ｇ－１·ｍｉｎ－１，Ｐ＜００１。血浆ＥＴ、ＴＸＢ２升高和ｒＣＢＦ下降在大面积卒中较小面积卒中明显，基底节卒中?
Objective To explore the plasma concentration of the endothelium derived vasoactive factors such as endothelin (ET), thromboxane B 2 (TXB 2), 6 keto prostaglandin F 1α (6 K PGF 1α ) and their effects on regional cerebral blood flow (rCBF) Methods Plasma ET, TXB 2, 6 K PGF 1α were measured with radioimmunoassay in 64 patients with acute stroke and 30 control subjects Meanwhile, the rCBF was determined using 133 Xe inhalation method in all patients and the control group The data of stroke group were studied by t test The linear correlation between alterations of vasoactive factors and rCBF was analysed Results The mean ET, TXB 2 plasma level [respectively (103 8±42 6) and (152 2±59 1) ng/L] was significantly higher in 64 stroke patients than in normal subjects [respectively (47 8±7 8) and (84 8±11 5) ng/L], P<0 01 The patients had lower plasma 6 K PGF 1α [(93 7±28 8) ng/L] as compared with the healthy controls [(104 7±17 4) ng/L], P<0 05 Meantime, rCBF in patients was significantly lower than that in healthy age matched controls [left: (46 6±8 8) mL·100 g -1 ·min -1 vs (62 2±7 1)mL·100 g -1 ·min -1 ; right: (47 2±8 2) mL·100 g -1 ·min -1 vs (64 5±7 1) mL·100 g -1 ·min -1 ; mean: (46 9±7 9) mL·100 g -1 ·min -1 vs (63 3±6 5) mL·100 g -1 ·min -1 , P<0 01] Moreover, plasma ET, TXB 2 in patients with large infarct or hemorrhage volume were markedly higher than those of patients with small foci; to the opposite, rCBF was decreased remarkably The same situation was seen while compared the date of patients with basilar nuclei stroke with those of patients with lobar stroke Both ET and TXB 2 had a significant negative correlation with rCBF (r=-0 751, -0 454, P<0 01) Bilateral rCBF decrease was seen in 43 patients with unilateral stroke Conclusions This study suggests that there was endothelium dysfunction in the cerebral arteries of patients with acute stroke Plasma level of ET, TXB 2 and rCBF might be useful in assessment of brain damage caused by acute stroke
出处
《中华核医学杂志》
CAS
CSCD
北大核心
1999年第2期72-74,共3页
Chinese Journal of Nuclear Medicine
关键词
中风
内皮源
血管活性物质
脑血流量
RIA
Endothelins Thromboxane B 2 6 ketoprostaglandin F 1 alpha Radioimmunoassay Cerebrovascular disorders Brain Regional blood flow
