摘要
目前,临床上常使用阿司匹林进行心血管疾病的一、二级预防。阿司匹林可以非特异性地抑制环氧合酶,进而发挥抗动脉粥样硬化的作用。大量研究表明阿司匹林还可以通过非环氧合酶途径如抗氧化、调节血管舒缩、对炎症因子的转录调控等来发挥预防作用。本文就近年来阿司匹林抑制动脉粥样硬化作用机制方面的研究予以综述。
Atherosclerosis is the base of many cardiovascular diseases and aspirin has been widely used for the primary and secondary prevention of cardiovascular diseases, because it is proved that aspirin can reduce atherosclerosis. Pharmacologically, aspirin inhibits cyclooxygenase nonspecifically which inhibits inflammation at the same time, but the inhibition of inflammation cannot account for all. In recent years, many researchers have noticed that aspirin had a cyclooxygenase-independent way to attenuate atherosclerosis, anti-oxidation, regulating the systolic and diastolic ability of vessels by affecting NO release, and regulating the transcription of inflammatory cytokines are involved. This review focuses on recent researches on the mechanism of aspirin＇s anti-atherosclerotic effects.
出处
《现代生物医学进展》
CAS
2010年第19期3757-3759,共3页
Progress in Modern Biomedicine
