摘要
目的:探讨酒精性脂肪性肝病(AFLD)与非酒精性脂肪性肝病(NAFLD)的实验室指标的特点.方法:共1203例健康体检者纳入本研究,均接受腹部超声检查、血液常规检查和血液生化学检查.超声诊断脂肪性肝病(FLD)509例,男415例,女94例;非脂肪性肝病(NFLD)694例,男446例,女248例.根据中国脂肪肝诊疗指南,将509例FLD患者分为AFLD组与NAFLD组.其中,AFLD组106例(男105例,女1例),NAFLD组403例(男310例,女93例).结果:与NFLD组相比,FLD组的平均年龄较低(P=0.011)、BMI明显升高(P<0.001),白细胞(WBC)、红细胞(RBC)、血红蛋白(HGB)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、γ谷氨酰基转移酶(GGT)、白蛋白(ALB)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、尿酸(UA)(均P<0.001),碱性磷酸酶(ALP)、总蛋白(TP)、AST/PLT、AST/ALT和GGT/PLT明显增高(P值分别为0.015、0.026、0.001、0.000和0.000),高密度脂蛋白胆固醇(HDL-C)、AST/GGT和TBIL/GGT显著降低(均P<0.001).与NAFLD组比较,AFLD组的平均年龄低(P<0.001),HGB、GGT、ALB、UA等显著升高(均P<0.001),TG、AST、RBC、ALT、AST/PLT、AST/ALT和GGT/PLT也高于NAFLD组(P值分别为0.007、0.005、0.011、0.027、0.012、0.014和0.002);而UREA、AST/GGT和TBIL/GGT低于NAFLD组(均P<0.001).结论:血液常规和血清生化学检测不仅能够区分FLD和NFLD,而且还能够区分AFLD或NAFLD.
AIM：To compare routine blood parameters and blood biochemical parameters between patients with alcoholic fatty liver disease（AFLD）and non-alcoholic fatty liver disease（NAFLD）.METHODS：A total of 1 203 subjects,who underwent physical examination,including measurement of abdominal circumference and blood pressure,routine blood examination,biochemical examination and two-dimensional ultrasound,were included in this study.Of these subjects,509（415 men and 94 women）were diagnosed with fatty liver disease（FLD）and 694（446 men and 248 women）without FLD by two-dimensional ultrasound.According to the Guidelines for the Diagnosis and Treatment of Alcoholic Liver Disease,subjects with FLD were divided into two groups：AFLD group（n=106,105 men and 1 woman）and NAFLD group（n= 403,310 men and 93 women）.RESULTS：Subjects with FLD had a younger mean age and a higher BMI than subjects without FLD（P=0.011 and 0.000,respectively）.WBC,RBC,HGB,ALT,AST,GGT,ALB,TG,TC,LDL-C,FBG,UA（P0.001 for all）,ALP（P= 0.015）,TP（P=0.026）,AST/PLT ratio（P=0.001）,AST/ALT ratio（P0.001）,and GGT/PLT ratio（P0.001）were higher and HDL-C,AST/GGT ratio,and TBIL/GGT ratio（P0.001 for all） were lower in subjects with FLD than in those without FLD.Subjects with AFLD had a younger mean age（P0.001）,a higher HGB,GGT,ALB,UA（P0.001 for all）,TG,AST,RBC,ALT（P= 0.007,0.005,0.011 and 0.027,respectively）,AST/PLT ratio,AST/ALT ratio,and GGT/PLT ratio（P=0.012,0.014 and 0.002,respectively）,and a lower UREA,AST/GGT ratio and TBIL/GGT ratio（P0.001 for all）than those with NAFLD.CONCLUSION：Routine blood examination and blood biochemical examination are useful in distinguishing patients with and without FLD as well as those with AFLD and NAFLD.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第25期2654-2659,共6页
World Chinese Journal of Digestology
基金
辽宁省科技厅科技攻关基金资助项目
No.2007225011-1
辽宁省教育厅一般基金资助项目
No.2008745~~
关键词
酒精性脂肪性肝病
非酒精性脂肪性肝病
血常规
生化检查
Alcoholic fatty liver disease
Nonalcoholic fatty liver disease
Routine blood test
Biochemical examination
