摘要
持留菌(persisters)是细菌种群中所占比例不到0.1%的一类特殊亚群,具有与种群内普通菌、抗性突变菌所不同的特征,其形成机制复杂,不易分离培养.持留菌可通过"休眠-生长-增殖"应对逆境的胁迫,维持自身生存和菌体结构稳定,在生物膜的多药耐受性与多金属耐性中发挥着重要作用,对于维持微生物群落结构稳定具有重要意义.本文从持留菌的研究历程、特点、基因调控机制及其对微生物膜的耐药性与多金属耐性的影响等方面进行了综述,并对今后的研究方向进行了展望.
Persisters are a group of special subpopulation of bacteria,only occupying 0.1% of the whole population but having the characteristics different from the ordinary bacteria and resistant mutants.They have complex formation mechanism,and are difficult to isolate and culture.The persisters can adapt to the adverse environment via ＂dormancy-growth-proliferation＂to maintain their survival and cell structure stability,and play a vital role in the multi-drug and multi-metal tolerance of microbial biofilm,being of great significance in maintaining the stability of microbial community structure.This paper reviewed the research progress on the characteristics of persisters,their gene regulation mechanisms,and their effects on the multi-drug and multimetal tolerance of microbial biofilm.The related research directions in the future were also prospected.
出处
《应用生态学报》
CAS
CSCD
北大核心
2010年第10期2707-2714,共8页
Chinese Journal of Applied Ecology
基金
国家自然科学基金项目(40701161)
国家高技术研究发展计划项目(2009AA063101)资助
关键词
持留菌
微生物膜
毒素-抗毒素分子
多药耐性
金属耐性
persisters
microbial biofilm
toxin-antitoxin（TA） modules
multi-drug tolerance（MMD）
multi-metal tolerance（MMT）
