摘要
目的 探讨国内慢性胰腺炎（CP）患者烟酒摄入量与发生胰腺钙化间的关系。方法按入院时有无胰腺钙化分为两组进行比较分析，再将无胰腺钙化者出院后有无新发胰腺钙化分为新发组和持续无钙化组。Logistic回归或Cox比例风险模型进行逐步回归分析胰腺钙化的风险因素。结果1997年1月到2007年7月共收治并成功随访449例CP患者，248例有胰腺钙化；201例无胰腺钙化，其中13例出院后新发生胰腺钙化。入院时胰腺钙化者的发病年龄小、病史长、糖尿病和腹泻发生率高。首发年龄≤40岁、酒精摄入量〉20g／d、糖尿病和腹泻为胰腺钙化风险因素；过量饮酒为无胰腺钙化CP患者新发生钙化的唯一风险因素（OR3．2）。结论饮酒增加CP患者胰腺钙化风险，建议戒酒；吸烟的作用需进一步研究。
Objective To investigate the relationship between alcohol and smoking and the development of pancreatic calcification in chronic panereatitis （CP） in China. Methods The patients were divided into two groups according to the presence of pancreatic calcification at admission and the data were analyzed; furthermore, the discharged patients without pancreatic calcification were divided into two groups as newly diagnosed pancreatic calcification group and persistent non-pancreatic calcification group. Logistic regression and Cox proportional-hazards model was used for multivariate analysis of the risk factors for pancreatic calcification. Results From January1997 to July 2007, 449 patients with CP were enrolled and followed up successfully. 248 patients presented with pancreatic calcification at admission; among the 201 patients presented without pancreatic calcification, 13 patients developed pancreatic calcification after discharge. Patients with pancreatic calcification had a young age at onset, long CP history, higher incidence of diabetes mellitus and diarrhea. Age at onset ≤ 40, alcohol intake over 20 g/day, and diabetes mellitus and diarrhea were risk factors for pancreatic calcification. The only risk factor of development of pancreatic calcification after discharge was excessive alcohol intake （ OR ： 3.2 ）. Conclusions Alcohol intake increased the risk of pancreatic calcifications, suggesting the patients abstain from alcohol intake. Further studies are necessary to clarify the role of smoking.
出处
《中华胰腺病杂志》
CAS
2010年第5期309-311,共3页
Chinese Journal of Pancreatology
关键词
胰腺炎
慢性
钙质沉着症
吸烟
饮酒
Panereatitis, chronic
Calcinosis
Smoking
Alcohol drinking
