摘要
目的探讨己酮可可碱(PTX)对下肢慢性静脉性溃疡患者外周血黏附分子和炎症因子表达的影响。方法下肢静脉性溃疡患者18例(治疗组)采用PTX进行治疗,另取8例健康者作对照(对照组)。分别于治疗前、治疗后3、30、90d采用流式细胞术、ELISA、放射免疫法测定外周血CD11b、ICAM-1及TNF-α的表达水平。结果下肢静脉性溃疡患者外周血CD11b、ICAM-1及TNF-α表达均明显高于对照组(P<0.01)。经PTX治疗30d后,CD11b、ICAM-1、TNF-α表达均比治疗前明显下降(P<0.01);但治疗90d后CD11b、ICAM-1仍高于对照组(P<0.05)。结论 PTX可抑制白细胞与内皮细胞黏附,减少局部组织的炎症损伤,但治疗下肢慢性静脉性溃疡的机制仍需深入研究。
Objective To ivestigate the influence of pentoxifylline（PTX） on the expressions of adhesion molecule and inflammatory factor in peripheral blood in patients with chronic venous ulcer（CVU）.Methods The expressions of CD11b on neutrophils,serum intercellular adhesion molecule-1（ICAM-1） and tumor necrosis factor-α（TNF-α） were detected in 18 CVU patients treated with PTX（group PTX） and 8 healthy people as the controls（group C） before and on the 3rd,30th and 90th day after treatment.Results The expressions of CD11b,ICAM-1 and TNF-α were higher in group PTX than those in group C before treatment （P0.01）,which were significantly reduced after treated with PTX for 30 days compared to before in group PTX （P0.01）.The expressions of CD11b and ICAM-1 were still higher in group PTX than those in group C after treated with PTX for 90 days（P0.05）.Conclusion Pentifylline may restrain the adhersive attraction between leucocyte and endothelial cells and reduce the inflammatiory damage to the dermal issue.Further studies are needed to clarify the mechanism for PTX to treat CVU.
出处
《江苏医药》
CAS
CSCD
北大核心
2010年第18期2161-2163,共3页
Jiangsu Medical Journal
