摘要
目的:探讨MEBT/MEBO及贝复济促进慢性难愈合创面再生与修复的作用,并期望为皮肤溃疡的治疗提供新的思路和有效治疗的新方法。方法:临床观察:采用随机对照的方法选取60例符合入选标准的患者分为治疗组(美宝湿润烧伤膏组)30例和对照组(贝复济组)30例。观察用药3天、14天、21天、28天各组难愈合创面的创面面积、创面深度、疼痛程度、肉芽生长情况及用药疗效、创面愈合时间、愈合后瘢痕形成情况,并统计分析。结果:MEBO组在用药3天时缓解伤口疼痛与贝复济组有差异,P<0.05;MEBO组在用药后7天缓解疼痛与贝复济组有差异,P<0.05,说明MEBO缓解疼痛效果优于贝复济;用药后7天MEBO组肉芽组织生长情况与贝复济组相同,P>0.05;MEBO组在用药14天、21天、28天时促进肉芽组织生长,减小伤口深度与面积大小与贝复济组无差异,P>0.05,说明MEBO在加速伤口愈合,促进肉芽组织生长方面与贝复济效果等同,两组痊愈率接近;MEBO组与贝复济组创面愈合时间无差异;SI评分MEBO组与贝复济组有差异,P<0.05,说明MEBO减少瘢痕形成优于贝复济。结论:MEBO在减轻疼痛,减少瘢痕愈合方面优于贝复济,而在促进伤口愈合,促进肉芽组织生长方面与贝复济效果无差异。
Objective： To explore the regeneration and restoration effect of MEBT/MEBO and bFGF in treating chronic and refractory wounds so as to find a new method to treat skin chronic ulcers. Method： 60 patients meeting inclusion criteria were collected and divided into treatment group （ MEBO group, n = 30） and control group （ bFGF group, n = 30） randomly. The changes of the size, depth, feeling of pain, the growth of granulation, wound healing time and scar formation were observed and recorded in two groups at the time point of 3^th, 14^th, 21^st and 28^th day after MEBO applied. The results obtained were analyzed respectively. Results ： There were significance differences （ P 〈 0.05 ） in relieving pain ob- served at the 3^rd day and 7^th day respectively between two groups. The effect of MEBO in relieving pain was better than that of bFGF. There was no significance difference （ P 〉 0.05 ） in growth of granulation tissue between two groups at the 7th day and no significance difference （ P 〉 0. 05 ） in accelerating granulation growth, reducing wound size and depth observed at the point of 14^th, 21^st, 28^th day between two groups. It showed that the effect of accelerating wound healing and granulation growth in MEBO group was similar to that in bFGF group. There were similar results obtained between two groups in healing rate, so no difference between two groups. The differences （ P 〈 0. 05 ） in SI score was observed between two group, ME- BO was better than bFGF. It meant that the effect of reducing scar formation in MEBO group was better than that in bFGF group. Conclusion： MEBO ointment is superior to bFGF in effect of reducing pain and sear formation. But, there is no significance difference between two groups in improving wound healing and promoting growth of granulation tissue.
出处
《中国烧伤创疡杂志》
2010年第5期346-350,共5页
The Chinese Journal of Burns Wounds & Surface Ulcers
基金
2008年国家自然科学基金项目(项目批准号:30860356)
2007年广西科学研究与技术开发计划项目(项目批准号:0719006-3-8)
