摘要
目的:探讨早期应用丙戊酸钠对脑卒中患者功能康复和生存质量的影响。方法:84例脑卒中患者随机分为观察组和对照组各42例,均接受常规神经内科治疗和康复训练及治疗随访,观察组患者加服丙戊酸钠600 mg/d。治疗前后采用SF-36健康调查量表、改良爱丁堡-斯堪的那维亚量表(MESSS)及Barthel指数(BI)对患者生存质量、神经功能缺损程度及ADL能力进行评价。结果:经过平均(16.5±3.7)d的治疗,出院时2组患者MESSS评分与治疗前比较明显下降,ADL评分明显提高(均P<0.05,0.01),SF-36中情感职能、精神健康、社会功能维度评分观察组明显高于对照组(P<0.05);6个月后随访,观察组各量表评分与出院时比较仍继续改善(P<0.01),且明显优于对照组(P<0.05);而对照组各量表评分与出院时比较改善不明显。结论:丙戊酸钠的早期应用更有利于脑卒中患者躯体、心理和社会功能的康复,能明显提高生存质量。
Objective： To observe the effect of early treatment with sodium valproate on rehabilitation and quality of life（QOL） of patients with stroke.Methods： Eighty-four patients with stroke were randomly divided into two groups： observation group and control group.All patients received clinical treatment and function training.The patients in observation group were treated with sodium valproate.Efficacy was assessed with 36-item Short Form Health Survey Questionnaire（SF-36）,Scoring Scale（MESSS） and activity of daily living（ADL）.Results： After 6 months,the scores of MESSS in observation group were significantly less,and those of SF-36 and ADL were significantly greater than in control group.Conclusion： Early treatment with sodium valproate could significantly improve the functions and QOL of patients with stroke.
出处
《中国康复》
2010年第5期346-348,共3页
Chinese Journal of Rehabilitation
关键词
脑卒中
丙戊酸钠
康复
生存质量
stroke
sodium valproate
rehabilitation
quality of life
