摘要
目的观察大鼠脑打击伤后脑白介素1β(IL-1β)的变化规律,探讨地塞米松、尼莫同及血府逐瘀注射液对大鼠脑损伤后脑组织IL-1β的影响。方法采用SD大鼠打击伤模型,使用地塞米松、尼莫同及血府逐瘀注射液干预,应用免疫组织化学方法检测打击伤后4个时间点IL-1β蛋白的表达情况。结果打击伤后大鼠脑组织中IL-1β的表达水平明显升高(P<0.01);尼莫同与血府逐瘀注射液干预后IL-1β明显下降(P<0.01);而血府逐瘀组的IL-1β表达量下降,与尼莫同组相比较差异有显著性(P<0.01)。结论尼莫同与血府逐瘀注射液均可以降低创伤性脑损伤后的IL-1β表达,减轻继发性炎症反应。
ObjectiveTo observe the rule of IL-1β in rats after traumatic brain injury and to investigate the change of IL-1βafter administration of dexamethasone,nimotop and Xuefuzhuyu injection.MethodsIL-1β expression of SD rat brain injury model was detected at 4 time points by immunohistochemistry method after administration of dexamethasone,nimotop and Xuefuzhuyu injection.ResultsExpression level of IL-1βin rats after trauma significantly elevated（P 0.05）.The expression of IL-1βdecreased obviously（P 0.05） after administration of nimotop and Xuefuzhuyu injection.However,the expression of IL-1βwas obviously lower in Xuefuzhuyu group than in nimotop group（P 0.05）.ConclusionsNimotop and Xuefuzhuyu injection both can lower expression level of IL1βand alleviate secondary inflammatory reaction.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第17期2570-2572,2578,共4页
China Journal of Modern Medicine
基金
2008年广东省医学科研基金项目(No:A2008484)
2008年湛江市科技攻关项目(No:2008C05006)
