摘要
目的:探讨了慢性肾炎患者在输注红细胞前后Ferritin、MMP-2和MMP-9水平的变化。方法:应用放射免疫分析和酶联法对32例慢性肾炎患者进行了输注红细胞前后Ferritin、MMP-2和MMP-9检测,并与35名正常人组作比较。结果:慢性肾炎患者在输注红细胞前血清Ferritin和MMP-9水平非常显著地低于正常人组(P<0.01),而MMP-2水平则显著地高于正常人组(P<0.01)。经2周输注红细胞后则与正常人组比较无显著性差异(P>0.05)。结论:检测慢性肾炎患者输注红细胞治疗前后血清Ferritin、MMP-2和MMP-9水平的变化对其病情的发展和预后的判断均具有重要的临床价值。
Objective To explore the changes of serum Ferritin,MMP-2 and MMP-9 contents after transfusion of red blood cells in patients with chronic nephritis.Methods Serum Ferritin （with RIA） and serum MMP-2,MMP-9 （with ELISA） levels were measured in 32 patients with chronic nephritis both before and after a course of transfusion of red blood cells and 35 controls.Results Before transfusion,the serum Ferritin,MMP-9 levels in the patients were significantly lower than those in controls （P〈 0.01） ,while the serum MMP-2 levels were significantly higher （P〈 0.01） .After a course of two weeks’transfusion of red blood cells,the serum Ferritin,MMP-2 and MMP-9 levels in the patients were not significantly different from those in controls （P〈 0.05） .Conclusion Determination of serum Ferritin,MMP-2 and MMP-9 levels is clinically useful for management of patients with chronic nephritis.
出处
《放射免疫学杂志》
CAS
2010年第5期506-508,共3页
Journal of Radioimmanology
关键词
慢性肾炎
血清铁蛋白
基质金属蛋白酶-2
基质金属蛋白酶-9
chronic nephritis
serum ferritin （SF）
matrix metalloproteinase-2 （MMP-2）
matrix metalloproteinase-9 （MMP-9）
