摘要
目的观察慢性肾衰(CRF)血透患者的血浆同型半胱氨酸(HCY)和B型钠尿肽(BNP)水平及与心脑血管并发症的关系。方法对42例透析组患者在服用叶酸和VitB12前后及23例健康对照组作了HCY的测定。结果 CRF血透患者血浆HCY和BNP水平分别为28.42±9.53μmol/L和193.39±48.4μmol/L,明显高于对照组的11.93±4.96μmol/L和26.64±9.81μmol/L(P<0101)。伴有心脑血管病变者血浆HCY和BNP水平均明显高于无心脑血管病变者。透析组患者服用叶酸和VitB128周前后HCY水平下降明显(P<0.01),BNP水平变化不明显。结论 CRF血透患者存在高HCY血症和高BNP血症,服用叶酸、VitB12可降低HCY水平,可能防止心脑血管并发症的发生。
Objective To evaluate the significance of plasma homocysteine（HCY）and B-type natriuretic peptide（BNP）in patients with chronic renal failure（CRF）receiving hemodialysis.Methods Plasma HCY and BNP levels were measured in 42 renal failure patients receiving hemodialysis both before and after 8 weeks oral administration of folic acid（5mg tid）and VitB12（500μg tid）as well as in 23 controls.Results The plasma levels of HCY and BNP in CRF patients receiving hemodialysis before taking folic acid and VitB12（25.12±12.51μmol/L）were 28.42±9.53μmol/L and 193.39±48.4μmol/L which were significanlty higher than those in controls（8.2±4.5μmol/L,and 26.64±9.81 μmol/L respectively）（P〈0.01）.Among these patients,levels of HCY and BNP in the subjects with cardiovascular complications were significantly higher than those in the subjects without cardiovascular complications（P〈0.01）.The values of HCY after 8 weeks treatment with folic acid and VitB12 were significantly dicreseaed（P〈0.01）.Conclusion CRF patient receiving hemodialysis has abnormally high levels of plasma HCY and BNP,treatment with folic acid and VitB12 might be beneficial in lessening the complications.
出处
《中国老年保健医学》
2010年第5期10-11,共2页
Chinese Journal of Geriatric Care
