摘要
目的通过测定帕金森病患者尿白蛋白、尿α1-微球蛋白,了解是否存在肾功能的损害。方法收集病史资料,采用放射免疫分析方法,对32例帕金森患者和40例健康对照的尿白蛋白、尿α1-微球蛋白进行检测;同时比较发病1～5年、6～10年尿白蛋白、尿α1-微球蛋白结果。结果帕金森病患者与健康对照尿白蛋白分别为(483±437)μg/h、(311±209)μg/h(P<0.05);帕金森患者与健康对照的尿α1-微球蛋白结果分别为(400±242)μg/h、(286±203)μg/h(P<0.05);发病1～5年、6～10年帕金森患者尿白蛋白分别为(284±138)μg/h、(619±519)μg/h(P<0.05);发病1～5年、6～10年帕金森患者尿α1-微球蛋白分别为(396±249)μg/h、(447±266)μg/h(P>0.05)。结论帕金森患者尿白蛋白、尿α1-微球蛋白增高,提示可能存在肾功能损害,并且损害程度可能与病程呈正相关。
Objective To explore whether there is renal functional lesion in patients with Parkinson＇ s disease （PD） by detecting the levels of urinary albumin and α1-microglobulin. Methods The patients＇ history data were collected, and radioimmunoassay was used to detect the levels of urinary albumin and α2-microglobulin in 32 PD patients and 40 healthy subjects, and the detection results of the levels of urinary albumin and α2-microglobulin were compared between 1 ~ 5yr pathogenesy and 6 - 10yr pathogenesy. Results The average contents of urinary albumin in PD patients and healthy subjects were （483± 437 ）μg/h, （311 ±209）μg/h respectively,there was a significant difference between the two groups （ P 〈 0.05 ）, and the average contents of α2-microglobulin in PD patients and healthy subjects were （400 ± 242 ） μg/h, （ 286 ±203 ） μg/h respectively, there was a significant difference between the two groups （ P 〈 0.05 ）. The average contents of urinary albumin in 1 -5yr pathogenesy group and 6 ~ 10yr pathogenesy group were （284 ± 138 ）g/h, （619 ± 519 ）μg/h respectively, there was a significant difference between the two groups （ P 〈 0.05 ）. The average contents of α2-microglobulin in 1 ~ 5yr pathogenesy group and 6 ~ 10yr pathogenesy group were （396 ± 249）μg/h, （447 ± 266）μg/h respectively,there were no significant difference between the two groups （ P 〉 0.05）. Conclusion The levels of urinary albumin and α1-microglobulin in patients with Parkinson＇s disease increase, which suggests that the patients may have renal function lesion ,furthermore the lesion degree may be positively correlated with the course of disease.
出处
《河北医药》
CAS
2010年第20期2816-2817,共2页
Hebei Medical Journal
