摘要
目的:探讨血浆和淋巴细胞内亲环素A(CyP A)水平及CyP A自身抗体与溃疡性结肠炎(UC)的关系。方法:用双抗体夹心ELISA法测定67例活动期、49例缓解期UC患者和50名健康体检(正常对照组)者血浆和淋巴细胞内CyP A水平同时用间接ELISA法检测抗CyP A自身抗体,统计分析其间关系。结果:UC活动期患者血浆和淋巴细胞CyP A水平均显著高于正常对照组和缓解期UC患者(P<0.01),但正常对照组与缓解期UC患者差异无统计学意义(P>0.05)。UC活动期患者抗CyPA自身抗体阳性者也显著高于缓解期UC患者及正常对照组(P<0.01)。结论:血浆和淋巴细胞内CyP A升高和抗CyP A自身抗体阳性可反映UC活动性。
Objective：To study the relationship between cyclophilin A（CyP A）,its autoantibody and the activity of ulcerative colitis（UC）.Methods：The CyP A levels of plasma and lymphocytes were detected by double sandwich ELISA in 67 active,49 inactive UC patients and 50 normal controls.Anti-CyP A autoantibody was measured by indirect ELISA.Results：The CyP A levels of plasma and lymphocytes in active UC subjects were significantly higher than those in inactive UC or normal controls（P0.01）.But there was no statistical significance between inactive UC and normal controls（P0.05）.The positive rate of anti-CyP A autoantibody in active UC patients was markedly higher than those in inactive UC or normal controls（P0.01）.Conclusions：The increase of CyP A levels of plasma and lymphocytes and the positive expression of anti-CyP A autoantibody in active UC patients are two useful markers which reflect the activity of UC.
出处
《蚌埠医学院学报》
CAS
2010年第10期990-992,共3页
Journal of Bengbu Medical College
基金
中国博士后科学基金特别资助项目(200801375)
