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雌激素在肠易激综合征内脏高敏感性机制中作用的研究进展 被引量:5

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摘要 肠易激综合征(irritable bowel syndrome,IBS)是一种以慢性腹部疼痛和排便习惯改变为特征的功能性胃肠病,女性多发,发病率随年龄增加逐渐降低,绝经期雌激素替代治疗又加重了肠易激综合征的发病率,提示这种性别差异与雌激素水平有关。目前内脏高敏感性机制被认为是IBS的特征性病理生理学基础,雌激素影响内脏高敏感性的机制还不清楚。研究表明,雌激素可以通过脊髓-中枢途径和自主神经途径影响内脏感觉,雌激素影响迷走神经功能可能是内脏高敏感性的机制之一。本文综述近年来有关雌激素与内脏高敏感性之关系的研究。
作者 董晓 陈胜良
出处 《生理科学进展》 CAS CSCD 北大核心 2010年第5期362-364,共3页 Progress in Physiological Sciences
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参考文献7

  • 1Ruigómez A,García Rodríguez LA,Johansson S,et al.Is hormone replacement therapy associated with an increased risk of irritable bowel syndrome? Maturitas,2003,44:133-140.
  • 2Ito A,Takeda M,Furue H,et al.Administration of estrogen shortly after ovariectomy mimics the anti-nociceptive action and change in 5-HT1A-like receptor expression induced by calcitonin in ovariectomized rats.Bone,2004,35:697-703.
  • 3张睿,吴斌,林春,林国威.新生期结肠刺激及性别对幼鼠内脏痛敏感性的影响[J].中国疼痛医学杂志,2008,14(3):167-171. 被引量:6
  • 4Tang B,Ji YP,Richard J,et al.Estrogen alters spinal NMDA receptor activity via a PKA signaling pathway in a visceral pain model in the rat.Pain,2008,137:540-554.
  • 5Khasar SG,Isenberg WM,Miao FJ,et al.Gender and Gonadal Hormone Effects on Vagal Modulation of Tonic Nociception.J Pain,2001,2:91-100.
  • 6Grundy D.5-HT system in the gut:roles in the regulation of visceral sensitivity and motor functions.Eur Rev Med Pharmacol Sci,2008,12(Suppl 1):63-67.
  • 7Chen SL,Wu XY,Cao ZJ,et al.Subdiaphragmatic vagal afferent nerves modulate visceral pain.Am J Physiol Gastrointest Liver Physiol,2008,294:G1441-G1449.

二级参考文献11

  • 1张青,梁列新,钱伟,侯晓华.性别及动情周期对大鼠内脏感觉影响的研究[J].中华消化杂志,2005,25(1):49-50. 被引量:10
  • 2王玮,余保平,李天津,姚永刚.卵巢激素对内脏高敏感大鼠背根神经节细胞上5-HT_3受体的影响[J].中华消化杂志,2005,25(11):692-693. 被引量:4
  • 3孙梅,滕旭.儿童慢性腹痛的诊断和治疗[J].中国实用儿科杂志,2007,22(1):9-12. 被引量:25
  • 4American Academy of Pediatrics and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. Chronic abdominal pain in children. Pediatrics, 2005, 115:370-381.
  • 5Vanhatalo S, van-Nieuwenhuizan O. Fetal pain? Brain and development, 2000, 22: 145 -150.
  • 6Fishpein M, Bernaral B, Ehrlich C. The Primary Care Physiciang Approach to Functional Abdominal Pain in Childhood. J Clin Gastroenterol, 2006, 40: 497-503.
  • 7Groholt EK, Stigum H, Nordhagen R, et al. Recurrent pain in children, socio-economic factors and accumulation in families. European J Epidemiol, 2003, 18 : 965-975.
  • 8Gobble R, Swenny C, Fishbein M. The impact of the september 11, 2001 terrorist attacks and aftermath on the incidence of recurrent abdominal pain syndrome in children. Clin Pediatr, 2004, 43 : 275 - 277.
  • 9Al-chaer ED, Kawasaki M, Pasricha PJ. A new model of chronic visceral hypersensitivity in adult rats induces by colon initation during postnatal development. Gastroenterol,2000,119 : 1276 - 1285.
  • 10Ji Y, Murphy AZ, Traub RJ. Estrogen modulates the visceromotor reflex and esponses of spinal dorsal horn neurons to eolorectal stimulation in the rat. J Neurosei, 2003, 23 : 3908 - 3915.

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