摘要
目的观察比较艾司西酞普兰合并喹硫平治疗难治性抑郁症的临床疗效及可行性。方法对符合中国精神疾病诊断与分类标准第3版(CCMD-3)抑郁症诊断标准和难治性标准的70例患者随机分为艾司西酞普兰合并喹硫平36例为研究组,单用艾司西酞普兰34例为对照组,采用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、副反应量表(TESS)于治疗前及治疗后1、2、4、6周末分别评定临床疗效及副作用。结果两组治疗后HAMD和HAMA评分较治疗前均有显著性降低(P(0.01)。研究组HAMD和HAMA评分于各周末分别明显高于对照组(P<0.05),两组副反应评分无显著差异,均无严重副反应。结论艾司西酞普兰合并喹硫平治疗难治性抑郁症疗效确切,起效快,副作用较轻。
Objective To explore the efficacy and side effects of escitalopram combined with quetiapine in the treatment of refractory dpression. Methods A total of 70 patients with refractory dpression were randomly assigned to two group. One group was treated with escitalopram and the other with a combination of escitalopram and quetiapine for 6 weeks. The efficacy was measured with Hamilton Depression Scale（HAMD） and Hamilton Anxiety Scale（HAMA）. The side effects were evalua- ted with the Treatment Emergent Symptom Scale（TESS）. Results The reduction rates of HAMD and HAMA scores in study group were significantly higher than that in control group after treatment（P 〈 0.01 ）. In the l t h, 2th,4th and 6th weekend of treatment,the scores of HAMD and HAMA in study group were significantly lower than that in control group. Compared with control group,the study group had significantly higher effective rate（P 〈0.05）. Side effects in both groups were not serious, and there had no significantly differences between two groups. Conclusion A combination of eseitalopram and quetiapine would have better efficacy, it is take into effect fastly with few side effects in the treatment of refractory depression .
出处
《精神医学杂志》
2010年第5期359-360,共2页
Journal of Psychiatry
