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阿尔茨海默病的血管危险因素及其药物治疗 被引量：3

Vascular risk factors and drug therapy for Alzheimer’s disease
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摘要 除了已知的遗传、β淀粉样蛋白沉积、神经递质异常、Tau蛋白异常磷酸化等因素外,脑血管病变等血管危险因素(VRF)在阿尔茨海默病(AD)的发病过程中也起着重要的作用。但VRF对AD发病机制的具体影响尚未阐明。本文根据目前该领域最新研究对VRF在AD发病过程中的作用做一综述,以期阐明VRF诱发AD的各种可能机制以及其他各诱发因素之间的关系。 Addition to genetic factors, deposition of βamyloid protein, anormality of neurotransmitter and phosphorylation of Tau-protein, vascular risk factors（VRFs） play important roles in the pathogenesis of AD as well. However, the specific effects remain unclear. This review describes the effects of VRFs in order to clarify the pathogenesis of AD induced by VRFs and the relationship between VRFs and other risks of AD.
作者 陈其龙 董文心
机构地区 上海医药工业研究院药理室
出处 《世界临床药物》 CAS 2010年第10期631-635,共5页 World Clinical Drug
关键词 阿尔茨海默病 血管危险因素 载脂蛋白E 脑低灌注 Alzheimer’s disease vascular risk factor apolipoprotein E cerebral hypoperfusion
分类号 R749.16 [医药卫生—神经病学与精神病学] R972.4 [医药卫生—药品]
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参考文献25

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二级参考文献17

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世界临床药物
2010年 第10期

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