摘要
目的：观察镉对离体家兔空肠力学特性的影响。方法：取大耳白兔２０只，各制３个离体空肠平滑肌条标本，共６０个，随机分成５组，分别以盐水和４个剂量氯化镉液对肌条作循环灌注，用张力感受器测量离体空肠平滑的主动张力（ＰＴ）、基础张力（ＲＴ）、主动张力最大收缩速率（ｄＴ／ｄｔｍａｘ）和主动张力最大舒张速率（－ｄＴ／ｄｔｍａｘ）。结果：镉离子１．００８×１０－４ｍｏｌ／Ｌ组见ＰＴ、ｄＴ／ｄｔｍａｘ、－ｄＴ／ｄｔｍａｘ均有不同程度降低，ＲＴ亦有部分降低，随着镉离子浓度增大，观察指标均明显降低，在镉离子２．０１６×１０－４ｍｏｌ／Ｌ组，有８个标本停止主动收缩，随着镉离子浓度增加，停止主动收缩的标本例数随之增加。这些作用可通过换液得到恢复，并且氯化钙可对抗镉的这种作用。结论：镉离子可直接引起空肠肌收缩力降低，早期此作用可被钙离子逆转。
S: Effect of cadmium chloride on active tension,basic tension,maximal velocity of contraction or relaxation (dT/dtmax)of isolated jejunum from rabbits was studied in vitro.The results showed that dT/dtmax,-dT/dtmax,active and basic tension were decreased significantly,and the decsease in dT/dtmax and -dT/dtmax appeared to be the most significant.These effects could be inhibited by using new culture medium and the cadmium effects were antogonized by calcium.
基金
河南省自然科学基金
关键词
镉中毒
空肠
力学特性
cadmium
jejunum
mechanical properties
rabbit
