摘要
以各种取代苯并噻唑为侧链结构,对Strobilurins类杀菌剂苯噻菌酯的药效团部分进行修饰,设计合成了18个结构新颖的苯并噻唑硫醚类化合物,结构经1HNMR,MS,元素分析确证.并用X-ray单晶衍射测定了化合物5,5-二甲基-4-甲氧基-3-[2-(苯并噻唑-2-硫甲基)苯基]-2(5H)-呋喃酮(6a)的晶体结构.初步的生物活性测试结果表明,在200mg/L的剂量下部分化合物表现出一定的杀菌活性.
Eighteen novel thioethers were designed and synthesized by modifying the pharmacophore of the strobilurin fungicide with various substituted benzothiazole rings as the side chain structure.Their structures were characterized by 1H NMR,MS techniques and elemental analysis,and the single crystal structure of compound 6a was determined by X-ray diffraction analysis.The preliminary bioassay showed that some of them exhibited certain fungicidal activities.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2010年第10期1567-1573,共7页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.20702018)资助项目
关键词
苯并噻唑
合成
杀菌活性
晶体结构
benzothiazole
synthesis
fungicidal activity
crystal structure
