摘要
以己二酰氯、哌嗪类化合物和二溴代物为原料,合成了一系列未见文献报道的双螺环哌嗪季铵盐类化合物.通过1HNMR,13CNMR和元素分析确定了化合物的结构.在小鼠醋酸扭体模型上初步评价了它们的镇痛活性,发现多数化合物显示具有较好的镇痛活性,总结出了相应的构效关系.
A series of dispirocyclopiperazinium analogues were synthesized by the reaction of hexanedioyl chloride,piperazine analogues and dibromides.The structures of target compounds were characterized by 1H NMR,13C NMR spectra and elemental analysis.Preliminary bioassay test indicated that most of the compounds showed significant analgesic activity,and the structure-activity relationship was revealed.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2010年第10期1559-1562,共4页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.NSFC20772009)资助项目
关键词
哌嗪
螺环哌嗪季铵盐
合成
镇痛活性
构效关系
piperazine
spirocyclopiperazinium
synthesize
analgesic activity
structure-activity relationship
