摘要
微波辐射下,二氨基硫脲与乙酸反应制得3-甲基-4-氨基-1,2,4-三氮唑-5-硫酮(1),在无水乙醇中以三乙胺作为反应的缚酸剂,1与[二-(4-氟苯基)]甲基氯经微波辐射制得中间体3-甲基-4-氨基-5-[二-(4-氟苯基)]甲硫基-1,2,4-三氮唑(2),然后中间体2与芳香醛经缩合反应制得了10个Schiff碱3a～3j.合成的10个目标化合物通过熔点测定和质谱、红外光谱、核磁共振氢谱分析、元素分析对其结构进行确证.
Under microwave irradiation conditions,ten Schiff bases 3a～3j have been synthesized.Firstly thiocarbazide was reacted with acetic acid to prepare 4,5-dihydro-3-methyl-4-amino-1,2,4-triazole-5-thione（1）.Then compounds 1 reacted with [bi-（4-fluorophenyl）]methyl chloride in the presence of triethylamine and ethanol to form the key intermediate 2.The target compounds 3a～3j were synthesized by the condensation between substituted benzaldehyde and the intermediates 2 in acetic acid medium.The structures of target compounds have been confirmed by IR,1H NMR,MS techniques and elemental analysis.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2010年第10期1555-1558,共4页
Chinese Journal of Organic Chemistry
基金
西南民族大学青年重点基金(No.08NQZ002)
学生创新基金(No.F200912003)资助项目
