摘要
目的:探讨不同血浆纤维蛋白源(FIB)浓度对机采血小板聚集功能(PAGT)的影响。方法:收集80份机采血小板样品,分别在采集后4h和24h检测PAGT和FIB含量,根据FIB浓度(1.5～2.4g/L、2.5～3.4g/L、3.5～4.4g/L、4.5～5.4g/L)将PAGT测定结果分为4组进行比较分析。结果:血小板最大聚集率在4h时FIB浓度为4.5～5.4g/L组明显高于FIB浓度为1.5～2.4g/L和2.5～3.4g/L组;24h时FIB浓度为4.5～5.4g/L组明显低于FIB浓度为1.5～2.4g/L和2.5～3.4g/L组;各组24h均明显低于4h,差异有统计学意义(P<0.05或P<0.01)。结论:FIB浓度越高对机采血小板保存期内PAGT影响越大。
Objective：To investigate the influences of different plasma fibrinogen（FIB）concentrations on machine-collected platelet aggregation function（PAGT）.Method：80 machine-collected platelet samples were collected.PAGT and FIB content were detected respectively 4h and 24h after the samples were taken.The results of PAGT were divided into 4 groups according to the different FIB concentrations for comparing and analyzing.The FIB concentration of each group were 1.5～2.4g/L、2.5～3.4g/L、3.5～4.4g/L and 4.5～5.4g/L.Result：In 4h the maximum agglutination in group of 4.5～5.4g/L was obviously higher than that of the groups of 1.5～2.4 g/L and 2.5～3.4g/L.In contrast,in 24h the group of 4.5～5.4g/L was obviously lower than that of the groups of 1.5～2.4g/L and 2.5～3.4g/L.The FIB concentration of each group in 24h was markedly lower than those in 4h.The ANOVA analysis showed significant difference（P0.05 or P0.01）.Conclusion：The higher fibrinogen concentration,the greater impact on machine-collected PAGT in retention period.
出处
《临床血液学杂志（输血与检验）》
CAS
2010年第5期580-581,共2页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
关键词
FIB
血小板
聚集功能
fibrinogen
platelet
aggregation function
