摘要
抵抗素(resistin)是近年来发现的一个新脂肪细胞因子,最初在动物实验被用于联系肥胖、胰岛素抵抗和2型糖尿病。但随着进一步在人类实验的研究中发现,抵抗素能调节炎症反应而非胰岛素敏感性,研究发现抵抗素能促进炎症发生,炎症因子也能调节抵抗素的表达。动脉硬化是一种慢性亚临床性炎症,大量的体外研究提示抵抗素有可能作为一种促炎因子,通过激活内皮功能,诱导平滑肌增殖迁移,促巨噬细胞的脂质沉积,导致脂质代谢紊乱等途径,促进动脉粥样硬化的发生与发展。
Resistin was found in recent years which is a new adipocytokine.It was initially thought to be a link in obesity,insulin resistance and type 2 diabetes mellitus in animal studies.However,recent researches found that resistin was mainly associated with in-flammation and not associated with insulin sensitivity in human.Atherosclerosis is a disease with low-grade inflammation.It has been shown recently that resistin plays a role in the development of atherosclerosis.Resistin as a pro-inflammation factor that could activate endothelial dysfunction,induce lipidoses in macrophages and promote smooth muscle cells proliferation and migration and dislipideamia pathway,so as to contribute to the atherogenic process.
出处
《现代生物医学进展》
CAS
2010年第18期3598-3600,共3页
Progress in Modern Biomedicine
关键词
抵抗素
胰岛素抵抗
炎症
动脉硬化
Resistin Insulin resistance Inflammation Atherosclerosis
