摘要
目的 分析不同精子参数对卵胞质内单精子注射术（ICSI）临床结局的影响.方法 选取在我院接受ICSI治疗的不孕夫妇235对（共299个ICSI周期）,根据男方精液的来源和参数不同,我们将299个ICSI周期分为4组：精液正常组（A组,70例、96个周期）,严重少弱精子症组（B组,33例、44个周期）,附睾精子组（C组,23例、28个周期）和睾丸精子组（D组,109例、131周期）.比较4组的受精率、优质胚胎率、种植率和临床妊娠率等.结果 A组年龄明显大于其他3组（P〈0.01）.A、B、C、D组患者行ICSI卵数分别为937、476、344、1543,单周期移植胚胎数分别为2.74±0.49、2.22±0.47、2.07±0.26、2.12±0.43,A组单周期移植胚胎数显著多于其他各组（P〈0.01）.D组受精率（62.80%）显著低于其他3组（75.03%、72.06%、78.02%）（P〈0.01）.C组优质胚胎率（35.31%）显著低于其他3组{47.65%、48.40%、45.71%）（P〈0.01）,4组间临床妊娠率和种植率并无明显差异（P〉0.05）.结论 不同参数的精子虽然可以影响ICSI后胚胎早期的发育,但对临床妊娠率并无明显影响.
Objective To evaluate the effect of sperm parameters on the outcome of intracytoplasmic sperm injection （IC- SI）. Methods Total 299 cycles of 235 infertile couples were included in the present study. Patients were divided into 4 groups according to the quality and source of sperm： group A included 96 cycles of 70 patients with ejaculated normal semen, group B included 44 cycles of 33 patients with ejaculated abnormal semen,; group C included 28 cycles of 23 patients eith epididymal spermatozoa and group D included 131 cycles of 109 patients with testicular spermatozoa. The rates of fertilization, good-quality embryo, implantation and pregnancy were compared among 4 groups. Results The average female age of group A was signifi- cantly higher than that of other groups （P〈0.01）. The average embryo transfer （ET） numbers of group A, B, C, D were 2.74 ＋- 0.49, 2.22 ＋_0.47, 2.07 ＋_0.26 and 2.12 ＋_0.43, among 4 groups group A had the highest （P〈0.01）. The fertilization rate of group D （62.80%） was significantly lower than that of other groups （75.03%, 72.06% and 78.02%, P 〈 0.01 ）and the rate of good-quality embryo in group C（35.31%） was significantly lower than that of other groups（47.65%, 48.40% and 45.71%, P 〈 0.01 ）. There was no significant difference in implantation rate and pregnancy rate among 4 groups. Conclusion The parameters of sperm may af- fect the early development of embryos after ICSI, but they have little effect on pregnancy rate.
出处
《浙江医学》
CAS
2010年第9期1357-1359,共3页
Zhejiang Medical Journal
