摘要
目的:探讨针刺对化疗所致白细胞减少的辅助治疗作用。方法:选取化疗后白细胞减少患者86例,随机分为粒细胞集落刺激因子(G-CSF)+针刺组及G-CSF组,每组43例,两组患者2次化疗后均使用G-CSF4次,G-CSF+针刺组穴取支沟、曲池、合谷等,G-CSF组只注射G-CSF,治疗观察周期共45天。比较两组患者治疗周期第10、31天疗效及第10、17、24及45天外周白细胞计数及中性粒细胞分类。结果:第10天时两组的有效率均为100.0%(43/43);第31天时,G-CSF+针刺组的有效率为97.7%(42/43),高于G-CSF组的81.4%(35/43)(P<0.05)。第10、17、24天时G-CSF+针刺组白细胞数高于G-CSF组(均P<0.01)。第10、17、24天时,G-CSF+针刺组成熟中性粒细胞比例高于G-CSF组(均P<0.05)。结论:针刺可以提高G-CSF的疗效,延缓G-CSF停用后的白细胞降低,促进中性粒细胞分化成熟,是改善化疗引起白细胞减少的较好方法。
Objective To explore the adjunctive therapeutic effects of acupuncture for leukopenia induced by chemotherapy. Methods Eighty-six cases with leukopenia after chemotherapy treatment were randomly divided into a granulocyte colony-stimulating factor （G-CSF） plus acupuncture （A） group and a G-CSF group, 43 cases in each group. After chemotherapy treatments, the patients of both groups were treated with G-CSF for 4 times, with acupuncture at Zhigou （TE 6）, Quchi （L1 11）, Hegu （L1 4）, etc. added in the G-CSF plus A group, for an observation cycle of 45 days. Their therapeutic effects on the 10th and 31st day and peripheral white blood cell （WBC） counts and neutrophilic granulocyte classification on the 10th, 17th, 24th, 45th day after treatment were compared. Results After they were treated on the 10th day, the effective rates were both 100.0% （both 43/43）, and on the 31st day, the effective rate of 98.9% （42/43） in the G-CSF plus A group was higher than 91.1% （35/43） in the G-- CSF group （P〈0.05）. The WBC counts in the G-CSF plus acupuncture group were both higher than those in the G-CSF group on the 10th, 17th and 24th day after treatment （all P〈0.05）. The ratios of mature neutrophilic granu- locyte in the G-CSF plus A group were all higher than those in the G-CSF group at the same time （all P〈0.01）. Conclusion Acupuncture can increase the therapeutic effect of O CSF, delay the decrease of WBC after discontinui- ng G-CSF, promote the neutrophilic granulocyte differentiating forward to mature and it is better for improving leukopenia induced by chemotherapy.
出处
《中国针灸》
CAS
CSCD
北大核心
2010年第10期802-805,共4页
Chinese Acupuncture & Moxibustion
关键词
白细胞减少
针刺疗法
化疗
粒细胞集落刺激因子
Leukopenia
Acupuncture Therapy
Chemotherapy
Granulocyte Colony-stimulating Factor （G-CSF）
