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间质成纤维母细胞与乳腺癌的发生发展研究进展 被引量：2

Advances in the study of stromal fibroblasts on breast cancer initiation and progression
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摘要 成纤维母细胞是乳腺癌间质的重要组成成分之一,该细胞与正常乳腺组织间质的成纤维细胞在生物学特性上存在明显的差异,不仅在肿瘤的发生、发展中起重要作用,而且与患者的预后密切相关。近年来,研究还显示乳腺癌相关成纤维母细胞与治疗效果有关,将成为乳腺癌治疗策略中不可忽略的一个方面。 Carcinoma-associated fibroblasts（CAFs） is an vital part of the stroma in breast cancer.There is a big differences in the biological features between the normal mammary fibroblasts and carcinoma-associated fibroblasts.CAFs plays a critical role in tumor initiation,growth,metastasis and prognosis as well.Recently,researches suggest that CAFs contribute to efficacy of antitumor therapy and targeting CAFs may become a viable approach for tumor treatment.
作者 张琳 康骅
机构地区 首都医科大学宣武医院普外科
出处 《现代肿瘤医学》 CAS 2010年第10期2072-2075,共4页 Journal of Modern Oncology
基金 国家自然科学基金资助项目(编号:30872516)
关键词 肿瘤相关成纤维母细胞 间质 乳腺癌 carcinoma associated fibroblasts（CAFs） stroma breast cancer
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献19

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共引文献1

同被引文献20

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引证文献2

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现代肿瘤医学
2010年 第10期

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