摘要
目的研究红松松针中的木脂素类成分，为松属植物的化学分类学研究提供依据。方法采用反复硅胶、聚酰胺、ODS、Sephadex LH-20柱色谱等方法进行分离纯化，根据理化性质和波谱分析对分离得到的化合物进行结构鉴定。结果从红松松针中分离得到8个化合物，分别鉴定为（＋）-异落叶松脂素-9-O-β-D-吡喃木糖苷（（＋）-isolariciresinol-9-O-β-D-xylopyranoside，1）、（＋）—异落叶松脂素-9-O-β-D-吡喃葡萄糖苷（（＋）-isolariciresinol-9-O-D-glucopyranoside，2）、7S，8R-苏式-3’，4，9’—三羟基-3-甲氧基-7，8-二氢苯并呋喃-1’-丙醇基新木脂素-9—O-α-1-毗喃鼠李糖苷（7S，8R-threo-3’，4，9＇-trihydroxy-3-methoxy-4’，7-epoxy-neolignan-9-O-α-L-rhamnopyranoside，3）、7S，8R-苏式-3’，9，9＇-三羟基-3-甲氧基-7，8-二氢苯并呋喃-1’-丙醇基新木脂素-4-O-α—L-吡喃鼠李糖苷（7S，8R-threo-3’，9，9＇-trihydroxy-3-methoxy-4’，7-epoxy-neoliglignan-4-O-α—L—rhamnopyranoside，4）、7R，8S-赤式-4，7，9-三羟基-3，3-二甲氧基-8-O-4-新木脂素-9＇-O-α-L-吡喃鼠李糖苷（7R，8S-erythro-4，7，9-trihydroxy-3，3’-dimethoxy-8-O-4＇-neolignan-9’-O-α-rham-nopyranoside，5）、7s，8S-苏式-4，7，9-三羟基-3，3’-二甲氧基-8-O-4。新木脂素-9’-O-α—L-吡喃鼠李糖苷（7S，8S—threo-4，7，9-trihydroxy-3，3’-dimethoxy-8-D4＇-neolignan-9’-O-α-L—rhamnopyr-anoside，6）、7S，8S苏式-3’，4，7，9-四羟基-3-甲氧基-8-O-4＇-新木脂素-9＇O-α-L-吡喃鼠李糖苷（7S，8S-threo-3’，4，7，9-tetrahydroxy-3-methoxy-8-O-4＇-neolignan-8’-O-a—L-rhamnopyranoside，7）、7R，8S-赤式-3’，4，9，9＇-四羟基-3-甲氧基-8—O—4。新木脂素-7—O-β-D-吡喃葡萄糖苷（7R，8S-erythro-3’，4，9，9＇-tetrahydroxy-3-methoxy-8-O-4＇-neolignan-7-O-β-D-glucopyranoside，8）。结论化合物1～8均为首次从红松中分离得到。
Objective To study the lignans of pine needles of Pinus koraiensis Sieb. et Zucc. Methods Compounds were isolated by chromatography on silica gel, ODS, Sephadex LH-20 columns, and their structures were elucidated by their physicochemical properties and spectral analysis. Results Eight compounds were ob- tained and identified as （ ＋ ）-isolariciresinol-9-O-β-D-xylopyranoside （ 1 ）, （ ＋ ） -isolariciresinol-9-O-β-D- glucopyranoside （ 2 ）, 7S, 8 R-threo-3 ＇ , 4,9 ＇-trihydroxy-3 -methoxy-4＇, 7-epoxy-neolignan-9-O-α-L-rhamnopy- ranoside （ 3 ）, 7S, 8R-threo-3＇, 9,9 ＇-trihydroxy-3-methoxy-4＇, 7-epoxy-neolignan-4- O -α-L-rhamnopyranoside （4）, 7 R, 8S-erythro-4 , 7 , 9-trihydroxy-3 , 3 ＇-dimethoxy-8-O-4 ＇-neolignan-9＇-O-α-L-rhamnopyranoside （ 5 ）, 7S, 8S-threo-4,7,9-trihydroxy-3,3 ＇-dimethoxy-8-O-4＇-neolignan-9＇-O-α-L-rhanmopyranoside （ 6 ）, 7S, 8S- threo-3＇ ,4,7,9-tetrahydroxy-3-methoxy-8-O-4＇-neolignan-9 ＇-O-α-L-rhamnopyranoside （ 7 ）, 7R, 8S-erythro- 3＇, 4, 9, 9＇-tetrahydroxy-3-methoxy-8-O-4＇-neolignan-7-O-β-D-glucopyranoside （8）. Conclusions Compounds 1-8 are obtained from Pinus koraiensis Sieb. et Zucc. for the for time.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2010年第10期797-802,共6页
Journal of Shenyang Pharmaceutical University
关键词
红松
松针
木脂素类化合物
化学成分
结构鉴定
Pinus koraiensis Sieb. et Zucc.
pine needle
lignans
chemical constituent
structure identifi- cation
