摘要
目的研究马鞭草中裂环环烯醚萜苷类成分。方法采用反复硅胶柱色谱、Sephadex LH-20柱色谱和半制备高效液相色谱等方法进行分离纯化，依据MS、1D和2DNMR（^1H-HCOSY、HMQC和HMBC）进行结构鉴定。结果从马鞭草乙醇提取物的正丁醇可溶部分分离得到5个裂环环烯醚萜苷类化合物，分别鉴定为三叶草苷（trifloroside，1）、macrophylloside（2）、3’-acetyl—swemside（3）、当药苦苷（swertiamarin，4）和龙胆苦苷（gentiopicmside，5）。结论化合物1—4为首次从马鞭草属植物中分离得到。
Objective To study the secoiridoid glycoside constituents of Verbena officinalis L. Methods The compounds were isolated by silica gel, Sephadex LH-20 and semiprep. HPLC column chromatography and MS,1D and 2D NMR（ ^1H-^1H COSY,HMQC and HMBC）were employed for the structural identification. Results Compounds 1- 5 were obtained from the n-BuOH soluble constituents of Verbena officinalis and their structures were identified as trifloroside （ 1 ）, macrophylloside （ 2 ）, 3＇-acetylsweroside （ 3 ）, swertiamarin （4） and gentiopicroside （5）, which are secoiridoid glycosides. Conclusions Compounds 1-4 are isolated from the genus Verbena for the first time.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2010年第10期793-796,共4页
Journal of Shenyang Pharmaceutical University
基金
辽宁省教育厅科研基金资助项目(2004C073)
关键词
马鞭草
裂环环烯醚萜苷类
化学成分
结构鉴定
Verbena officinalis L.
secoiridoid glycoside
chemical constituent
structure identification
