摘要
目的观察原发性干燥综合征（ＳＳ）的神经系统病变及临床特征。方法选择了１８例在我院就诊的ＳＳ患者，合并神经系统损害不能以其他疾病解释。观察期间给予神经系统、病理及免疫学各项检查。结果显示了神经及精神病的多种多样临床表现。血清学检查免疫球蛋白升高，自身抗体阳性，病理检查脑血管炎表现。结论ＳＳ因累及的神经系统部位不同，临床表现多种多样。中枢神经系统病变临床过程大多较轻且迁延，脑血管炎为主要致病因素，并可形成脑软化灶及脑梗死。抗ＳＳＡ／ＳＳＢ抗体的出现可能更多的伴有内脏损害。出现中枢神经系统损害应立即给予糖皮质激素及免疫抑制剂治疗。
Objective To investigate the lesion of nervous system and
its clinical features of Sjgren syndrome (SS).Methods Eighteen SS patients with nervous
system injuries which could not be explained by other diseases have been selected.Tests of
nervous system,pathology and immunology were carried out during the observational
period.Results There were a variety of neuropsychiatric presentations.Serological examination
showed that the immunoglobulin was elevated and autoantibodies were positive and
pathological examination showed cerebral vasculitis. Conclusion SS shows a variety of clinical
manifestations because of the different positions of nervous system involvement.The clinical
process of central nervous system pathological changes is usually protractive and not serious.
Cerebral vasculitis is the main pathogenesis,which maybe forms encephalomalacia and
cerebral infarction.The presentation of antiSSA and antiSSB may be companied with more
lesions of organs.Corticosteroid and immunosuppressive agents must be given immediately
when the lesions of the central nervous system are present.
出处
《中华风湿病学杂志》
CAS
CSCD
1999年第2期90-91,共2页
Chinese Journal of Rheumatology
