摘要
目的探讨恩丹西酮、枢复宁、康泉预防化疗药物引起恶心呕吐的临床效果。方法采用随机对照法观察了对以顺铂为主化疗药物的止吐作用，选择病例分别为４０例、３２例及９５例。结果恩丹西酮、枢复宁、康泉对控制急性呕吐的有效率（ＣＲ＋ＰＲ）分别为：８５％、８４．４％、９６．８％，康泉与恩丹西酮、枢复宁比较均有统计学意义（Ｐ＜０．０５），而恩丹西酮与枢复宁两者比较无统计学意义（Ｐ＞０．０５）。呕吐完全控制率（ＣＲ）三者分别为６５％、７５％及８１．１％，康泉与恩丹西酮比较有统计学意义（Ｐ＜０．０５），而康泉与枢复宁及恩丹西酮与枢复宁比较均无统计学意义（Ｐ＞０．０５）。结论恩丹西酮与枢复宁对预防化疗药物引起的呕吐有效，而康泉的效果优于枢复宁及恩丹西酮。但是，康泉的价格昂贵，临床应用受到限制。
Objective To study the antiemetic effect of ondansetronQilu,ondansetron and granisetron after receiving cisplatin. Methods In a randomized cross over trial, 40,32 and 95 patients were studied separately. Results The effective rate (CR+PR) for acute emesis were 85% in patients treated with ondansetronQilu, 84.4% in those with ondansetron,and 96.8% in those with granisetron. The CR rate of emesis were 65%,75% and 81.1% in patients treated with ondansetronQilu, ondansetron and gransetron,respectively. The antiemetic effect of granisetron was higher than ondansetronQilu and ondansetron (P<0.05), but that of ondansetronQilu and ondansetron were the same (P>0.05). Conclusion The antiemetic effect of ondansetronQilu and ondansetron was good,but that of granisetron was better.
出处
《肿瘤研究与临床》
CAS
1999年第3期165-167,共3页
Cancer Research and Clinic
关键词
恩丹西酮
枢复宁
康泉
呕吐
预防
肿瘤
药物疗法
OndansetronQiluOndansetronGranisetronVomitingProphylaxis and control
