摘要
目的了解上皮性卵巢癌患者血清前白蛋白（ｐｒｅａｌｂｕｍｉｎ，简称ＰＡ）水平与上皮性卵巢癌肿瘤生物学行为的关系及其作为上皮性卵巢癌生物学瘤标的意义。方法采用琼脂糖免疫单向扩散法测定５８例上皮性卵巢癌、３５例上皮性卵巢瘤和３０例正常人血清前白蛋白。同时用放免法测定上述检测对象血清ＣＡ１２５。结果上皮性卵巢癌组血清ＰＡ低于上皮性卵巢瘤组及正常人组（Ｐ＝０．００３）。且肿瘤临床分期越晚、分化越差，ＰＡ水平越低（Ｐ＜０．００１；Ｐ＝０．０２７），有淋巴转移者血清ＰＡ较无淋巴转移者低（Ｐ＜０．００１）；术后肿瘤残存与血清ＰＡ低水平有关（Ｐ＝０．０１４）。ＰＡ与ＣＡ１２５呈负相关，Ｓｐｅａｒｍａｎ′ｓ系数为—０．６８（Ｐ＜０．０１），ＰＡ越低ＣＡ１２５越高，与上皮性卵巢癌恶性生物学行为一致。结论ＰＡ与上皮性卵巢癌恶性行为密切相关，可作为上皮性卵巢癌病情及预后估计较敏感的新指标。
Objective To clarify the impact of the epithelial ovarian carcinoma and the level of serum prealbumin, a potential new tumor marker for epithelial ovarian carcinoma. Methods Serum prealbumin was detected in 58 female patients with epithelial ovarian carcinoma,35 female patients with benign epithelial ovarian tumor and 30 normal controls by agar single diffusion technique,while serum CA125 was determined by radioimmunoassay. Results Low serum prealbumin was associated with malignant property in epithelial ovarian carcinoma. The lower serum prealbumin would be the later the clinical stage and the poorer the differentiation was (P<0.05).] The level of serum prealbumin was negatively related to the level of CA125. Spearmens coefficient was 0.68 (P<0.01). Conclusion Serum prealbumin may be a useful new marker for the evaluation of prediction and prognosis of epithelial ovarian carcinoma.
出处
《肿瘤研究与临床》
CAS
1999年第3期147-149,共3页
Cancer Research and Clinic
关键词
血清前白蛋白
上皮性
卵巢癌
肿瘤标记物
Serum prealbuminEpithelial ovarian carcinomaBiological properties Tumor marker
