摘要
目的：研究重症肌无力（ＭＧ）患者手术后血清乙酰胆碱受体抗体（ＡｃｈＲａｂ）与抗骨骼肌柠檬酸提取物抗体（ＣＡＥａｂ）的变化。方法：用固相酶联免疫吸附法测定血清ＡｃｈＲａｂ和ＣＡＥａｂ。结果：ＭＧ患者血清ＡｃｈＲａｂ和ＣＡＥａｂ的水平明显高于对照组（Ｐ＜０．０１）。ＡｃｈＲａｂ水平在手术后１个月开始下降（Ｐ＜０．０５），在手术后１年下降更明显（Ｐ＜０．０１）；ＣＡＥａｂ水平在手术后１个月和６个月下降不明显（Ｐ＞０．０５），在手术后１年下降有显著性差异（Ｐ＜０．０５）。手术后１年患者血清中ＡｃｈＲａｂ和ＣＡＥａｂ水平仍高于对照组（Ｐ＜０．０１）。结论：手术后血清ＡｃｈＲａｂ和ＣＡＥａｂ的检测有助于了解患者的病情。
Objective: To study the changes of serum acetylcholine receptor antibody (AchRab) and citric
acid extract antibody (CAEab) in myasthenia gravis (MG) after thymectomy. Methods5BZ: The
levels of serum AchRab and CAEab were measured with enzymelinked immunosorbent assay
(ELISA). Results :The levels of serum AchRab and CAEab in MG were significantly higher than
those in control group (P<0.01).The level of serum AchRab began to decrease at one month
(P<0.05) and markedly edcreased at one year (P<0.01) after thymectomy.The level of serum
CAEab decreased at one year after thymectomy. Conclusion :Detecting serum AchRab and
CAEab after thymectomy may assist to judge patients condition.
出处
《卒中与神经疾病》
1999年第2期86-87,共2页
Stroke and Nervous Diseases
关键词
重症肌无力
胸腺切除
乙酰胆碱
受体
抗体
CAEab
myasthenia
gravisacetylcholine receptor antibodycitric acid extract antibodythymectomy
