摘要
目的观察益肾清利方结合西药治疗肾虚湿浊型原发性肾病综合征的临床疗效。方法将80例肾虚湿浊型原发性肾病综合征患者随机分为治疗组和对照组(各40例),两组均予西医常规治疗方案(包括激素、免疫抑制剂、对症处理等),治疗组同时予益肾清利方加减治疗;两组疗程均为2个月;观察临床疗效及治疗后中医症状体征积分、24h尿蛋白定量、血清白蛋白、胆固醇、三酰甘油、血肌酐、尿素氮等指标的变化情况。结果治疗组、对照组总有率分别为95.0%、82.5%;组间疗效比较,差异有统计学意义(P<0.05)。两组治疗后中医症状、体征积分均明显降低(P<0.05);组间治疗后比较,差异均有统计学意义(P<0.05)。两组治疗前后24h尿蛋白定量、血清白蛋白、肌酐、尿素氮、总胆固醇和三酰甘油差异均有统计学意义(P<0.05);组间治疗后比较,24h尿蛋白定量、血清白蛋白、总胆固醇和三酰甘油差异有统计学意义(P<0.05)。结论益肾清利方结合西药可有效提高原发性肾虚湿浊型原发性肾病综合征的临床疗效,明显改善患者临床证候及相关实验室指标。
Objective To observe the clinical efficacy of integrated ＂Yishen Qingli Decoction＂ and western medicine in the treatment of primary nephrotic syndrome（PNS）.Methods Eighty cases of PNS were randomized into two groups： control group in which 40 cases were treated with routine modality and treatment group in which 40 cases were treated by ＂Yishen Qingli Decoction＂ and routine western modality,with a course of 2 months.The clinical efficacy,symptom scores,24 h quantitative urinary protein,plasma albumin,blood fat,and kidney function were observed before and after treatment.Results The totaJ effective rate was 82.5% in the control group and 95.0% in the treatment group,with a significant difference between the two groups（P〈0.05）.The symptom scores were reduced in both groups（P〈0.05）,with more significant reduction in the treatment group than in the control group（P〈0.05）.After treatment,24 h quantitative urinary protein,plasma albumin,blood fat and kidney function were obviously improved in both groups（P〈0.05）,with more significant improvement in the 24 h quantitative urinary protein,plasma albumin and blood fat in the treatment group than in the control group（P〈0.05）.Conclusion ＂Yishen Qingli Decoction＂ can improve the clinical symptoms and laboratory indexes of primary nephrotic syndrome of kidney deficiency and dampness turbidity.
出处
《上海中医药杂志》
2010年第10期35-37,共3页
Shanghai Journal of Traditional Chinese Medicine
关键词
原发性肾病综合征
中西医结合疗法
益肾清利方
Primary nephrotic syndrome
integrated Chinese and western medicine
＂Yishen Qingli Decoction＂
