摘要
不动杆菌已成为医院感染的主要致病菌。随着碳青霉烯类抗生素的广泛应用,其多重耐药菌尤其是碳青霉烯类耐药菌株的出现,给临床治疗带来了很大的难题。研究发现,不动杆菌对碳青霉烯类抗生素的耐药机制主要是灭活酶的产生,其中以染色体或质粒介导的各种碳青霉烯酶最为重要。而舒巴坦和β-内酰胺类药物合用对不动杆菌有一定的治疗协同作用。
Acinetobacter has been the major pathogen of nosocomial infection.With the wide use of carbapenems,the emergence of multi-resistant isolates especially those resistant to carbapenem,brings a great problem to clinical treatment.The production of inactive enzymes is the main mechanism for antibiotic resistance,particularly the production of carbapenemases mediated by chromosome or plasmid.Combinations of β-lactam antibiotics and sulbactam may show synergism or partial synergism for acinetobacter isolates.
出处
《浙江大学学报（医学版）》
CAS
CSCD
北大核心
2010年第5期542-547,共6页
Journal of Zhejiang University(Medical Sciences)
