摘要
目的应用多焦视网膜电图（muhifocalelectroretinogram，mfERG）观察激光光凝对于视网膜颞上分支静脉阻塞所致黄斑水肿的疗效。方法对视网膜颞上分支静脉阻塞合并黄斑水肿的病例，进行多焦视网膜电图检查，分析其一阶反应（FOK），N1、P1波振幅密度值及其潜伏期。结果中心凹处P1波振幅密度在光凝治疗后3个月开始恢复，治疗后6个月明显升高，与光凝治疗前相比差异具有统计学意义（P〈0．05、P〈0．01）；2环P1波潜伏期在光凝治疗后3个月比治疗前有所缩短（P〈0．05），到治疗后6个月时改善更加明显，与治疗前相比差异具有统计学意义（P〈0．01）。颞上象限视网膜P1波振幅密度值在治疗后一个月与治疗前相比下降，其差异具有统计学意义（P〈0．05）。结论激光光凝可以有效治疗视网膜分支静脉阻塞所致的黄斑水肿，多焦视网膜电图在疗效评估方面具有重要价值，P1波振幅密度和P1波潜伏期可作为评价疗效的敏感指标。
Objective To observe the therapeutic efficacy of laser photocoagulation for macular edema secondary to superior temporal branch retinal vein occlusion determined by multifocal electroretinogram. Methods Implemented multifocal electroretinogram examination to the patients with macular edema secondary to superior temporal branch retinal vein occlusion and analyzed the first-order kernel （FOK） responses： amplitude densities and latencies ofNl-wave, Pl-wave. Results The amplitude density of Pl-wave in fovea began to improve at the 3rd month post-treatment and the improvement was more obvious at the 6th month post-treatment with statistically significance （P〈0.05, P〈0.01）. The latency of Pl-wave in ring 2 shortened at the 3rd month post-treatment and the improvement was more obvious at the 6th month post-treatment with statistically significance （P〈0.05, P〈0.01）. Compared with pre-treatment value, the amplitude density of P1-wave in superior temporal retina decreased at the 1st month post-treatment with statistically significance （P〈0.05）. Conelusions Laser photocoagulation can alleviate the macular edema secondary to branch retinal vein occlusion. Multifocal electroretinogram technique has the significant value to evaluate the therapeutic efficacy. The amplitude density and latency of P 1-wave may be regarded as sensitive estimate indexes.
出处
《中国实用眼科杂志》
CSCD
北大核心
2010年第9期962-965,共4页
Chinese Journal of Practical Ophthalmology
关键词
视网膜分支静脉阻塞
黄斑水肿
激光光凝
多焦视网膜电图
Branch retinal vein occlusion
Macular edema
Laser photoeoagulation
Multifocal electroretinogram
