摘要
目的探讨蒙古族一大家系先天缺失牙的临床特点和遗传基础。方法采用临床检查与家系调查相结合的方法对该家系临床特点进行分析。结果该家系中连续5代都出现该病患者,且患者子女中发病率近1/2,亦无性别差异。该家系患者的临床特点,牙齿X线片等结果显示,本家系与已报道的其他民族先天缺失牙家系的特点并不完全一致。结论该蒙古族先天缺失牙家系以常染色体显性方式遗传,临床表型存在高度的异质性。
Objective To explore the clinical characteristics and genetic bases of non-syndromic oligodontia in a large Mongolian family.Methods Systematic analysis of this family was carried out by using clinical detection.Results Affected individuals of non-syndromic oligodontia were consecutively found in a five-generation family.The morbidity of the offsprings is nearly 1/2 and no sexual difference was observed.The analysis of clinical features as well as dental X-ray film showed that it was not completely the same compared with other families.Conclusion Non-syndromic oligodontia in this Mongolian family pertains to autosomal dominant disorder with high genetic heterogeneity in clinical phenotype.
出处
《现代口腔医学杂志》
CAS
CSCD
2010年第5期376-378,共3页
Journal of Modern Stomatology
基金
内蒙古自然科学基金(2009MS0904)
内蒙古民族大学重大项目(MDX2008038)
