摘要
微小核糖核酸(microRNAs,miRNAs)是一类长度约为22个核苷酸,参与基因转录后水平调控的非编码小分子RNA。参与生命的多个过程且与癌症发生发展有着密切的关系。最近研究发现,一些miRNA在前列腺癌(PCa)组织中异常表达,表明miRNA在PCa发病的分子机制中起着重要作用。随着人血清/血浆miRNA的不断深入研究,血清miRNA有望作为诊断PCa的潜在分子标志物。
MicroRNAs（miRNAs）,with the length of about 22 nucleotides,are a growing family of small non-protein-coding RNAs that function as post-transcriptional regulators of target genes,involved in multiple processes of life and closely related with tumorigenesis.Recently,some aberrantly expressed miRNAs have been discovered in the prostate,indicating that miRNA may play a critical role in the molecular mechanism of the pathogenesis of prostate cancer.With deeper studies on human serum and plasma miRNAs,serum miRNA is promising to be a potential diagnostic biomarker for prostate cancer.
出处
《中华男科学杂志》
CAS
CSCD
北大核心
2010年第9期844-849,共6页
National Journal of Andrology
基金
国家自然科学基金(30950100)~~
