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儿童急性肾损伤生物学标志 被引量：9

Biomarkers of acute kidney injury in children
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摘要 国际肾脏病和急救医学界已逐步以急性肾损伤（aeute kidney injury，AKI）取代急性肾功能衰竭（ARF）这一概念，旨在更确切地反映该临床综合征的本质和动态病理生理过程，有利于早期发现、早期诊断、早期治疗，从而改善预后。尽管随着人们对AKI的认识以及对其发生机制的研究日趋深入，有关其诊断、支持或辅助治疗措施也有了较大进展，但AKI的预后仍不容乐观，其重要原因之一就是缺乏敏感、实时、特异、简便的诊断与鉴别AKI的生物学标志物。
作者 黄文彦 钮小玲
机构地区 复旦大学附属儿科医院肾脏风湿科
出处 《中国实用儿科杂志》 CSCD 北大核心 2010年第10期745-750,共6页 Chinese Journal of Practical Pediatrics
关键词 急性肾损伤 生物标志 儿童 acute kidney injury biomarker children
分类号 R72 [医药卫生—儿科]
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参考文献59

  • 1Bagshaw SM, Bellomo R. Early diagnosis of acute kidney injury [J]. Curt Opin Crit Care, 2007, 13: 638-644.
  • 2Vaidya VS, Fergnson MA, Bonventre IV. Biomarkers of acute kidney injury [J]. Ann Rev Pharmacol Toxicol, 2008, 48: 463 -493.
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二级参考文献27

  • 1吉俊,丁小强,许迅辉,邹建洲,何建强,林贻梅,柏瑾,钱菊英.低渗非离子造影剂对冠状动脉介入诊疗术患者肾功能影响的前瞻性研究[J].中华肾脏病杂志,2006,22(7):388-392. 被引量：46
  • 2Wamoch DG. Towards definition and classification of acute kidney injury. J Am Soc Nephrol, 2005,16:3149-3150.
  • 3Supavekin S, Zhang W, Kucherlapati R, et al. Differential gene expression following early renal ischemia/reperfusion.Kidney Int, 2003,63:1714-1724.
  • 4Mishra J, Ma Q, Prada A, et al. Identification of neutrophil gelatinase-associated lipocalin as a novel urinary biomarker for ischemic renal injury. J Am Soc Nephrol, 2003,4:2534-2543.
  • 5Parikh C, Jani A, Melnikov VY, et al. Urinary interleukin- 18 is a marker of human acute tubular necrosis. Am J Kidney Dis, 2004,43:405-414.
  • 6Melnikov VY, Faubel S, Siegmund B, et al. Neutrophil- independent mechanisms of caspase-1 and IL-18-mediated ischemic acute tubular necrosis in mice. J Clin Invest, 2002,110:1083-1091.
  • 7Mehta R, Kellum J, Shah S, et al. Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Critical Care, 2007,11 :R31.
  • 8Goldstein SL. Pediatric acute kidney injury: it's time for real progress. Pediatr Nephrol, 2006,21:891-895.
  • 9American Society of Nephrology. American Society of Nephrology Research Report. J Am Soc Nephrol, 2005,16: 1886-1903.
  • 10Parikh CR, Mishra J, Thiessen-Philbrook H, et al. Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery. Kidney Int, 2006,70:199-203.

共引文献28

同被引文献110

引证文献9

二级引证文献57

中国实用儿科杂志
2010年 第10期

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