摘要
目的探讨急性一氧化碳（CO）中毒患者血浆同型半胱氨酸（Hcy）浓度与血清肿瘤坏死因子-α（TNF-α）水平与病情严重程度和对预后的关系。方法将82例急性CO中毒患者分为三组：A组轻度组、B组中度组和C组重度组，应用ELISA法对82例急性CO中毒患者的血浆Hcy浓度与血清TNF-α水平进行检测。结果重度组与中度组Hcy与TNF-α水平均明显高于轻度中毒组（P〈0．01），且重度组明显高于中度组（P〈0．05）；迟发性脑病患者均发生在重度组，其Hey与TNF-α水平与其他组的比较差异有显著性（P〈0．05）。结论检测急性CO中毒患者的血浆Hcy浓度与血清TNF-α水平，有助于评估急性期脑组织受损的严重程度及预测迟发性脑病的发生。
Objective To observe plasm homocysteine （Hcy）concentration and the serum levels of tumor necrosis factor-α （ TNF-α ） in patients and explore their relationship with the severe degree of acute carbonmonoxide poisoning and the prognostic value of the plasma homocysteine concentration and the serum levels of tumor necrosis factor-α. Methods 82 patients with acute carbon monoxide poisoning were divided into three groups ： group A （ gentleness poisoning group）, group B （ moderate poisoning group） and group C （ severe poison- ing group）. The levels of Hcy and TNF-α of 82 patients were detected respectively with Enzyme-linked immu- nosobent assay ELISA. Results The level of Hcy and TNF-α in group B and group C were significantly higher than that in the control group A （P 〈 0. 05 ）, Hcy and TNF-α level in group C was obviously higher than in group B also（ P 〈 0. 05 ）. There was statistically significant difference in the levels of Hcy and TNF-α between the patients with delayed encephalopathy which all occurred in group C and those in other groups（ P 〈 0. 05 ）. Conclusion Determination of Hcy and TNF-α level can contribute to assessing the severe degree of acute carbonmonoxide poisoning and it can also predict the occurrence of delayed encephalopathy.
出处
《中国临床实用医学》
2010年第10期98-99,共2页
China Clinical Practical Medicine
