摘要
目的:研究异甘草酸镁对大鼠非酒精性脂肪性肝炎(NASH)的防治作用。方法:SD大鼠40只,随机分为4组(n=10):对照组、模型组、烟酸组及异甘草酸镁组。除对照组外,其余各组每天给予脂肪乳剂和烟酸,异甘草酸镁。实验开始1周后断尾取血,测定血清脂质;3周后处死动物,测定血清三酰甘油(TG)、总胆固醇(TC)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、游离脂肪酸(FFA)、肿瘤坏死因子-α(TNF-α)和肝匀浆TG、TC、FFA,并行肝脏病理学检查。结果:模型组大鼠出现NASH,异甘草酸镁组能降低大鼠血清TG(P<0.05)、ALT(P<0.01)、FFA(P<0.05)、TNF-α(P<0.01),同时也能降低肝匀浆TG(P<0.01)、FFA(P<0.05),肝脂肪变性程度和炎症均明显减轻(P<0.05)。结论:异甘草酸镁对脂肪乳剂诱导的NASH大鼠有较好的防治作用。
OBJECTIVE To study the protective and therapeutic effects of magnesium isoglycyrrhizinate（MgIG） on nonalcoholic steatohepatitis in rats. METHODS 40 SD rats were randomized into control ,model ,nicotinic acid,MglG group（n = 10）. The control group were only fed with a standard diet and the other groups were fed with a standard diet and fat emulsion. At the same time, the control and model groups were fed with sodium carboxymethylcellulose, the other groups were fed with relative medicine. The serum TG, TC, ALT, AST, FFA, TNF-α and hepatic TG, TC, FFA were detected and with histologically. RESULTS The model group developed NASH after 3 weeks. MgIG significantly reduced TG（P〈0. 05） ,ALT（P〈0.01 ） ,FFA（P〈0. 05）and TNF-α（P〈0. 01 ）of the serum and TG（P〈0. 05） ,FFA（P〈0. 05） of the liver tissue,and ameliorated hepatocellu lar macrovesicular steatosis （P〈0. 05）. CONCLUSION MglG has protective and therapeutic effects on fat emulsion-induced NASH in rats.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2010年第18期1587-1589,共3页
Chinese Journal of Hospital Pharmacy
关键词
异甘草酸镁
非酒精性脂肪性肝炎
大鼠
防治作用
magnesium isoglycyrrhizinate
nonalcoholic steatohepatitis
rat
protective and therapeutic effects
