期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

VEGF-C和VEGF-D在非小细胞肺癌中的表达及临床意义

暂未订购
导出
摘要 目的探讨血管内皮生长因子(VEGF-C)和血管内皮生长因子-D(VEGF-D)在非小细胞肺癌组织中的表达与其临床病理学参数的关系。方法应用免疫组织化学方法检测105例非小细胞肺癌组织及肺部淋巴结中的表达。结果 61.5%非小细胞肺癌标本呈现VEGF-C表达阳性,51.4%非小细胞肺癌标本呈现VEGF-D表达阳性,且二者表达都与肺癌的淋巴结转移、分级密切相关(P<0.05)。结论 VEGF-C/VEGF-D的高表达可以作为评价纵膈淋巴结转移的分子指标之一,为NSCLC的临床治疗及预后判断提供一定的理论依据。
作者 王明晖 崔艳红 孙昊 吴晓梅
机构地区 哈尔滨医科大学附属二院呼吸内科 齐齐哈尔第一医院呼吸内科
出处 《齐齐哈尔医学院学报》 2010年第17期2705-2706,共2页 Journal of Qiqihar Medical University
关键词 非小细胞肺癌 VEGF-C VEGF-D 淋巴结转移
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献8

  • 1Juttner S,Wissmann C,Jons T,et al.Vascular endothelial growth factor-D and its receptor VEGFR-3:two novel independent prognostic markers in gastric adenoeareinoma[J].Clin Oncol,2006,24(2):228-240.
  • 2Yoon Ho Ko,Chan-Kwon Jung,Myung-Ah Lee,et al.Clinical Significance of Vascular Endothelial Growth Factors (VEGF)-C and-D in Resected Non-Small Cell Lung Cancer[J].Cancer Res Treat,2008,40(3):133-140.
  • 3陈敏,唐建武.VEGF-C在非小细胞肺癌中的表达及意义[J].肿瘤,2005,25(1):80-82. 被引量：8
  • 4Stacker SA,Achen MG,Jussila L,et al.Lymphangiogenesis andcancer metastasis[J].NatRevCancer,2002,2(5):573-583.
  • 5Adachi Y,Nakamura H.Kitamura Y,et al.Lymphatic vessel density in pulmonary adenocarcinoma immunohistochemically e-valuated with antipodoplanin or anti-D2-40 antibody is correlated with lymphatic invasion or lymph node metastases[J].PatholInt,2007,57(4):171-177.
  • 6Mylona E.Alexandrou P,Mpakali A,et al.Clinicopathological and prognostic significance of vascular endothelial growth factors (VEGF)-C and-D and VEGF receptor 3 in invasive breast carcinoma[J].Eur J Surg Oncol,2007,33(3):294-300.
  • 7Ishii H.Yazawa T.Sato H,et al.Enhancement of pleural dissemination and lymph node metastasis of intrathoracic lung cancer cells by vascular endothelial growth factors (VEGFs)[J].Lung Cancer,2004,45(3):325-337.
  • 8Kopfstein L,Veikkola T,Djonov VG,et al.Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis[J].Am J Pathol,2007,170(4):1348-1 361.

二级参考文献10

  • 1Oh SJ,Jeltsch MM,Birkenhager R,et al. VEGF and VEGFC: Specific induction of angiogenesis and lymphangiogenesis in the differentiated avian chorioallantoic membrane[J]. Dev Biol, 1997,188(1) : 96-109.
  • 2Valtola R, Salven P, Heikkila P,et al. VEGFR-3 and Its Ligand VEGF-C Are Associated with Angiogenesis in Brest Cancer [J]. Ameri J Pathol, 1999,154(5) :1381-1890.
  • 3Kitada Y,Amioka T,Haruma K,et al. Clinicopathological significance of vascular endothelial growth factor in human esophageal squamous cell carcinomas[J]. Int J Cancer, 2001,93(5) :662-666.
  • 4Akagi K, Ikeda Y, Miyazaki M, et al. Vascular endothelial growth factor-c expression in human colorectal cancer tissues [J]. B J cancer,2000,83(7) :887-891.
  • 5Tsurusaki T, Kanda S, Sakal H, et al. Vascular endothelail growth factor-c expression in human prostatic carcinoma and its relationship to lymph node metastasis[J]. B J Cancer,1999, 80 (12):309-313.
  • 6O-charoenrat P,Rhys-Evans P,A. Eccles S. expression of vascular endothelial growth factor family members in head and neck squamous cell carcinoma correlates with lymph node metastasis[J]. Cancer, 2001, 92(3) :556-568.
  • 7Joukov V, Kumar V, Sorsa T, et al. A recombinant mutant vascular endothelial growth factor-c that has lost vascular endothelial growth factor receptor-2 binding, activation, and vascular permeability activities[J]. J Bio chem, 1998,273 (12):6599-6602.
  • 8Tanaka K, Sonoo H, Kurebayashi J, et al. Inhibition of infiltration and angiogenesis by thrombospondin-1 in papillary thyroid carcinoma[J]. Clin Cancer Res, 2002, 8 (5): 1125-1131.
  • 9Ueda M, Terai Y, Yamashita Y, et al. Correlation between vascular endothelial growth factor-c expression and invasion phenotype in cervical carcinomas[J]. Int J Cancer, 2002, 98(3) :335-343.
  • 10Skobe M, Hamberg LM, Hawighorst T, et al. Concurrent induction of lymphangiogenesis, angi-Ogenesis,and macrophage recruitment by vascular endothelial growth factor-c in melanoma[J]. Am J Pathol,2001, 159(3) :893-903.

共引文献7

齐齐哈尔医学院学报
2010年 第17期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部