摘要
采用生物学方法、放射免疫方法测定30例老年健康对照者，27例老年冠心病患者和29例老年高血压患者血浆血小板活化因子（PAF）、血栓烷B2（TXB2）、和6-酮-前列素F1α（6-K-PGF1α）水平。并对14例冠心病患者、15例高血压患者和25例健康对照者作应激前后血浆的PAF、TXB2、6-K-PGF1α水平进行测定。结果表明：冠心病患者血浆PAF、TXB2水平较对照组显著增高（P＜0.01）．高血压患者血浆TXB2较对照组显著增高（P＜0．01）。老年冠心病患者应激后PAF、TXB2增加显著（P＜0．01）。这些结果表明：血浆PAF、TXB2、6-k-PGF1α检测时老年心血管患者在疾病的诊断，治疗和预后诊断有一定的临床价值。
The levels of plasma platelet-activating factor (PAF), Thromboxane B2(TXB2) and 6- Ketoprostaglandin F1∞ or (6-K-PGF1∞) in 30 healthy controls, 27 elderly patients with coronary artery disease and 29 elderly patients with hypertension were measured by bio-assay or RIA. The levels of plasma PAF、 TXB2 and 6-K-PGF1∞ in 14 patients with coronary artery disease，15 patients with hypertension and 25 bealthy controls were measured by emotional stress. The resul is showed that the patients with coronary artery disease had higher level of plasma PAF and TXB2 than the healthy controls (P<0. 01), the Patients with hypertension had higher level of plasma TXB2 than the healthy (P<0. 01). The elderly patients with coronary artery disease had higher level of plasma PAF and TXB2 after emotiohal stress (P<0. 01). It was suggested that the measurement of plasma PAF、TXB2 and 6-K--PGF1∞ may play a role in the diagnosis、 therapy and prognosis of the elderly patients with cardiovascular disease.
出处
《镇江医学院学报》
1999年第2期184-185,共2页
Journal of Zhenjiang Medical College
关键词
血小板活化因子
血栓烷B2
心血管疾病
老年人
Platelet-activating factor (PAF)
Thromboxane B_2(TXB_2)
6-keto-prostaglandin F_(1α)(6-K -PGF_(1α))
Coronary artery disease
